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NRN1L neuritin 1 like [ Homo sapiens (human) ]

Gene ID: 123904, updated on 22-May-2018

Summary

Official Symbol
NRN1Lprovided by HGNC
Official Full Name
neuritin 1 likeprovided by HGNC
Primary source
HGNC:HGNC:29811
See related
Ensembl:ENSG00000188038 Vega:OTTHUMG00000137541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNQ2446; cpg15-2; MRCC2446
Summary
The protein encoded by this gene is extracellular and enhances both neurite growth and neuronal survival. The encoded protein is found both as a GPI anchored membrane-bound form and as a secreted form. This activity-related ligand functions as a homodimer or heterodimer. [provided by RefSeq, Feb 2017]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See NRN1L in Genome Data Viewer
Location:
16q22.1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (67884878..67888855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67918781..67920271)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene centromere protein T Neighboring gene nuclear transport factor 2 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene protein serine kinase H1 Neighboring gene chymotrypsin like Neighboring gene proteasome subunit beta 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Pathways from BioSystems

General gene information

Markers

Homology

Clone Names

  • MGC118990, MGC118993

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
neuron projection extension IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348682.1NP_001335611.1  neuritin-like protein isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AY358782, BM715649
    UniProtKB/Swiss-Prot
    Q496H8
    Related
    ENSP00000459748.1, ENST00000576758.1
    Conserved Domains (1) summary
    pfam15056
    Location:4274
    NRN1; Neuritin protein family
  2. NM_198443.1NP_940845.1  neuritin-like protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_940845.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY358782
    Consensus CDS
    CCDS10850.1
    UniProtKB/Swiss-Prot
    Q496H8
    Related
    ENSP00000342411.3, OTTHUMP00000174845, ENST00000339176.7, OTTHUMT00000268872
    Conserved Domains (1) summary
    pfam15056
    Location:42117
    NRN1; Neuritin protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    67884878..67888855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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