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Casp4 caspase 4, apoptosis-related cysteine peptidase [ Mus musculus (house mouse) ]

Gene ID: 12363, updated on 2-Nov-2024

Summary

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Official Symbol
Casp4provided by MGI
Official Full Name
caspase 4, apoptosis-related cysteine peptidaseprovided by MGI
Primary source
MGI:MGI:107700
See related
Ensembl:ENSMUSG00000033538 AllianceGenome:MGI:107700
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Caspl; ich-3; CASP-4; Casp11; CASP-11
Summary
This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9. [provided by RefSeq, Apr 2015]
Expression
Biased expression in large intestine adult (RPKM 7.7), bladder adult (RPKM 4.0) and 14 other tissues See more
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Genomic context

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See Casp4 in Genome Data Viewer
Location:
9 A1; 9 2.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (5308816..5336791)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (5308849..5336791)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31429 Neighboring gene predicted gene, 31492 Neighboring gene predicted gene, 53496 Neighboring gene STARR-positive B cell enhancer ABC_E10532 Neighboring gene caspase 1 Neighboring gene caspase 12 Neighboring gene STARR-seq mESC enhancer starr_23174 Neighboring gene STARR-seq mESC enhancer starr_23175 Neighboring gene STARR-seq mESC enhancer starr_23176 Neighboring gene STARR-seq mESC enhancer starr_23177 Neighboring gene STARR-seq mESC enhancer starr_23178 Neighboring gene STARR-seq mESC enhancer starr_23179 Neighboring gene STARR-seq mESC enhancer starr_23180 Neighboring gene STARR-seq mESC enhancer starr_23181 Neighboring gene STARR-seq mESC enhancer starr_23183 Neighboring gene STARR-seq mESC enhancer starr_23184 Neighboring gene phosphoglucomutase 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis. Chen R, et al. Sci Adv, 2019 May. PMID 31131320, Free PMC Article
  2. Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Gabrielli E, et al. Infect Immun, 2015 May. PMID 25712931, Free PMC Article
  3. Cutting Edge: Caspase-11 Limits the Response of CD8+ T Cells to Low-Abundance and Low-Affinity Antigens. Bergsbaken T, et al. J Immunol, 2015 Jul 1. PMID 25980012, Free PMC Article
  4. Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Vanaja SK, et al. Cell, 2016 May 19. PMID 27156449, Free PMC Article
  5. Caspase-11 Plays a Protective Role in Pulmonary Acinetobacter baumannii Infection. Wang W, et al. Infect Immun, 2017 Oct. PMID 28760936, Free PMC Article

See all (298) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.
    Title: Role of caspase-11 non-canonical inflammasomes in retinal ischemia/reperfusion injury.
  2. TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.
    Title: TrxR1 is involved in the activation of Caspase-11 by regulating the oxidative-reductive status of Trx-1.
  3. Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation.
    Title: Inhibition of caspase-11 under inflammatory conditions suppresses chondrogenic differentiation.
  4. Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection.
    Title: Caspase-11 signaling promotes damage to hippocampal CA3 to enhance cognitive dysfunction in infection.
  5. Casp11 Deficiency Alters Subgingival Microbiota and Attenuates Periodontitis.
    Title: Casp11 Deficiency Alters Subgingival Microbiota and Attenuates Periodontitis.
  6. Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
    Title: Adipose tissue IL-18 production is independent of caspase-1 and caspase-11.
  7. Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.
    Title: Downregulation of HMGB1 carried by macrophage-derived extracellular vesicles delays atherosclerotic plaque formation through Caspase-11-dependent macrophage pyroptosis.
  8. Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
    Title: Dectin-1 aggravates neutrophil inflammation through caspase-11/4-mediated macrophage pyroptosis in asthma.
  9. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-beta deposition in Alzheimer's disease.
    Title: DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease.
  10. Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.
    Title: Catalytic activity and autoprocessing of murine caspase-11 mediate noncanonical inflammasome assembly in response to cytosolic LPS.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
NOT enables cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scaffold protein binding IEA
Inferred from Electronic Annotation
more info
  
enables scaffold protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in actin filament organization TAS
Traceable Author Statement
more info
 PubMed 
NOT involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in detection of lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ectopic germ cell programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of macrophage cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in non-canonical inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in non-canonical inflammasome complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of NLRP3 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of interleukin-18-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein autoprocessing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein autoprocessing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein maturation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in pyroptotic cell death IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyroptotic inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within pyroptotic inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyroptotic inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of NLRP1 inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NLRP1 inflammasome complex ISO
Inferred from Sequence Orthology
more info
  
part_of canonical inflammasome complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
part_of non-canonical inflammasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of non-canonical inflammasome complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
caspase-4
Names
caspase 11, apoptosis-related cysteine peptidase
caspase 11, apoptosis-related cysteine protease
caspase 4, apoptosis-related cysteine protease
caspase-11 short form splicing
protease ICH-3
NP_001366247.1
NP_001366248.1
NP_001366249.1
NP_001366250.1
NP_001366251.1
NP_001366252.1
NP_031635.2
XP_006509902.1
XP_036010472.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379318.1 → NP_001366247.1  caspase-4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (2) summary
    smart00115
    Location:66 → 315
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cl14633
    Location:1 → 29
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. NM_001379319.1 → NP_001366248.1  caspase-4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (1) summary
    smart00115
    Location:5 → 254
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  3. NM_001379320.1 → NP_001366249.1  caspase-4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (2) summary
    smart00115
    Location:122 → 370
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:5 → 85
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

  4. NM_001379321.1 → NP_001366250.1  caspase-4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (1) summary
    cl00042
    Location:3 → 196
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  5. NM_001379322.1 → NP_001366251.1  caspase-4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (1) summary
    smart00115
    Location:5 → 253
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  6. NM_001379323.1 → NP_001366252.1  caspase-4 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC141637
    Conserved Domains (1) summary
    smart00115
    Location:42 → 291
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

  7. NM_007609.3 → NP_031635.2  caspase-4 isoform 1

    See identical proteins and their annotated locations for NP_031635.2

    Status: REVIEWED

    Source sequence(s)
    AC141637, AK151547
    Consensus CDS
    CCDS22799.1
    UniProtKB/Swiss-Prot
    C6L648, O08735, P70343, Q3TAF3, Q6P8H1
    Related
    ENSMUSP00000027012.8, ENSMUST00000027012.14
    Conserved Domains (2) summary
    smart00115
    Location:122 → 371
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    cd08325
    Location:5 → 85
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    5308816..5336791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154579.1 → XP_036010472.1  caspase-4 isoform X1

    Conserved Domains (2) summary
    cd08325
    Location:28 → 108
    CARD_CASP1-like; Caspase activation and recruitment domain found in Caspase-1 and related proteins
    cl00042
    Location:145 → 327
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

  2. XM_006509839.2 → XP_006509902.1  caspase-4 isoform X2

    See identical proteins and their annotated locations for XP_006509902.1

    Conserved Domains (1) summary
    smart00115
    Location:5 → 254
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70343.2 GenPept UniProtKB/Swiss-Prot:P70343

Gene LinkOut

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