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Car4 carbonic anhydrase 4 [ Mus musculus (house mouse) ]

Gene ID: 12351, updated on 1-Mar-2024

Summary

Official Symbol
Car4provided by MGI
Official Full Name
carbonic anhydrase 4provided by MGI
Primary source
MGI:MGI:1096574
See related
Ensembl:ENSMUSG00000000805 AllianceGenome:MGI:1096574
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca4
Summary
Enables carbonate dehydratase activity. Predicted to be involved in bicarbonate transport and one-carbon metabolic process. Predicted to act upstream of or within carbon dioxide transport and regulation of pH. Located in membrane. Is anchored component of plasma membrane. Is expressed in cardiovascular system; genitourinary system; nervous system; and tail. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human CA4 (carbonic anhydrase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 148.4), placenta adult (RPKM 86.4) and 10 other tissues See more
Orthologs
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Genomic context

See Car4 in Genome Data Viewer
Location:
11 C; 11 51.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (84848580..84856880)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (84957754..84966054)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene myosin XIX Neighboring gene zinc finger, HIT type 3 Neighboring gene predicted gene, 33028 Neighboring gene predicted gene, 32917 Neighboring gene STARR-positive B cell enhancer ABC_E5257 Neighboring gene STARR-seq mESC enhancer starr_30231 Neighboring gene ubiquitin specific peptidase 32 Neighboring gene STARR-seq mESC enhancer starr_30232 Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene ATP synthase F(0) complex subunit C2, mitochondrial pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within carbon dioxide transport IC
Inferred by Curator
more info
PubMed 
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of pH IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
located_in transport vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonic anhydrase 4
Names
CA-IV
carbonate dehydratase IV
carbonic anhydrase IV
NP_031633.1
XP_006532158.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007607.2NP_031633.1  carbonic anhydrase 4 precursor

    See identical proteins and their annotated locations for NP_031633.1

    Status: VALIDATED

    Source sequence(s)
    AK165399, AL669859, BM935015
    Consensus CDS
    CCDS25190.1
    UniProtKB/Swiss-Prot
    Q64444
    UniProtKB/TrEMBL
    Q3U3I1
    Related
    ENSMUSP00000099483.4, ENSMUST00000103194.10
    Conserved Domains (1) summary
    cd03117
    Location:48276
    alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    84848580..84856880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532095.5XP_006532158.1  carbonic anhydrase 4 isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:1186
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...