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Car2 carbonic anhydrase 2 [ Mus musculus (house mouse) ]

Gene ID: 12349, updated on 13-Dec-2022

Summary

Official Symbol
Car2provided by MGI
Official Full Name
carbonic anhydrase 2provided by MGI
Primary source
MGI:MGI:88269
See related
Ensembl:ENSMUSG00000027562 AllianceGenome:MGI:88269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca2; CAII; Car-2; Ltw-5; Lvtw-5
Summary
Enables carbonate dehydratase activity. Involved in positive regulation of dipeptide transmembrane transport and regulation of intracellular pH. Acts upstream of or within several processes, including carbon dioxide transport; positive regulation of GABAergic synaptic transmission; and positive regulation of cellular pH reduction. Located in cytosol and myelin sheath. Is expressed in several structures, including alimentary system; brain; heart; metanephros; and sensory organ. Used to study autosomal recessive osteopetrosis 3. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (carbonic anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 556.3), liver E14.5 (RPKM 538.2) and 14 other tissues See more
Orthologs
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Genomic context

See Car2 in Genome Data Viewer
Location:
3 A1; 3 3.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (14951329..14965830)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (14886269..14900770)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 1 Neighboring gene cytochrome c oxidase, subunit VIc pseudogene Neighboring gene predicted gene, 41999 Neighboring gene carbonic anhydrase 3 Neighboring gene RIKEN cDNA A930001A20 gene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42000

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arylesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbonate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables carbonate dehydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in carbon dioxide transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within carbon dioxide transport IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within carbon dioxide transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cellular pH reduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular pH reduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dipeptide transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of chloride transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of intracellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monoatomic anion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of pH IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carbonic anhydrase 2
Names
carbonate dehydratase II
carbonic anhydrase II
NP_001344263.1
NP_033931.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357334.1NP_001344263.1  carbonic anhydrase 2

    Status: VALIDATED

    Source sequence(s)
    AC098725, AC123747, CD774528, CK618053
    Consensus CDS
    CCDS17251.1
    UniProtKB/Swiss-Prot
    Q9DCY9
    Conserved Domains (1) summary
    cl00012
    Location:1259
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. NM_009801.5NP_033931.4  carbonic anhydrase 2

    See identical proteins and their annotated locations for NP_033931.4

    Status: VALIDATED

    Source sequence(s)
    AC123747, AK002333, CD774528
    Consensus CDS
    CCDS17251.1
    UniProtKB/Swiss-Prot
    P00920, Q9DCY9
    Related
    ENSMUSP00000029078.8, ENSMUST00000029078.9
    Conserved Domains (1) summary
    cl00012
    Location:1259
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    14951329..14965830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)