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Car8 carbonic anhydrase 8 [ Mus musculus (house mouse) ]

Gene ID: 12319, updated on 7-May-2024

Summary

Official Symbol
Car8provided by MGI
Official Full Name
carbonic anhydrase 8provided by MGI
Primary source
MGI:MGI:88253
See related
Ensembl:ENSMUSG00000041261 AllianceGenome:MGI:88253
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca8; wdl; Cals; Carp; Cals1
Summary
Predicted to enable hydro-lyase activity. Acts upstream of or within phosphatidylinositol-mediated signaling. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; ear; genitourinary system; and respiratory system. Used to study cerebellar ataxia, mental retardation and dysequlibrium syndrome. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome. Orthologous to human CA8 (carbonic anhydrase 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 76.1) and lung adult (RPKM 3.9) See more
Orthologs
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Genomic context

See Car8 in Genome Data Viewer
Location:
4 A1; 4 3.53 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (8141491..8239226, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (8141493..8239041, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23860 Neighboring gene STARR-seq mESC enhancer starr_09499 Neighboring gene STARR-seq mESC enhancer starr_09500 Neighboring gene STARR-seq mESC enhancer starr_09501 Neighboring gene STARR-seq mESC enhancer starr_09503 Neighboring gene STARR-seq mESC enhancer starr_09504 Neighboring gene STARR-seq mESC enhancer starr_09505 Neighboring gene STARR-seq mESC enhancer starr_09507 Neighboring gene STARR-seq mESC enhancer starr_09510 Neighboring gene STARR-seq mESC enhancer starr_09511 Neighboring gene predicted gene, 54230 Neighboring gene STARR-seq mESC enhancer starr_09514 Neighboring gene STARR-seq mESC enhancer starr_09515 Neighboring gene STARR-seq mESC enhancer starr_09516 Neighboring gene STARR-seq mESC enhancer starr_09517 Neighboring gene STARR-seq mESC enhancer starr_09518 Neighboring gene predicted gene, 42252 Neighboring gene predicted gene 11810

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Spontaneous (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
carbonic anhydrase-related protein
Names
CA-RP VIII
CA-VIII
carbonic anhydrase VIII
carbonic anhydrase-like sequence 1
NP_001406892.1
NP_031618.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419963.1NP_001406892.1  carbonic anhydrase-related protein

    Status: VALIDATED

    Source sequence(s)
    AL772336
    UniProtKB/Swiss-Prot
    P28651, Q8CF58, Q91XF6
  2. NM_007592.4NP_031618.2  carbonic anhydrase-related protein

    See identical proteins and their annotated locations for NP_031618.2

    Status: VALIDATED

    Source sequence(s)
    AL772336
    Consensus CDS
    CCDS17954.1
    UniProtKB/Swiss-Prot
    P28651, Q8CF58, Q91XF6
    Related
    ENSMUSP00000063511.7, ENSMUST00000066674.8
    Conserved Domains (1) summary
    cd03120
    Location:36290
    alpha_CARP_VIII; Carbonic anhydrase alpha related protein, group VIII. Carbonic anhydrase related proteins (CARPs) are sequence similar to carbonic anhydrases. Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    8141491..8239226 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941799.1 RNA Sequence

  2. XR_004941800.1 RNA Sequence

  3. XR_004941801.1 RNA Sequence