Cacng2 calcium channel, voltage-dependent, gamma subunit 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacng2provided by MGI
Official Full Name: calcium channel, voltage-dependent, gamma subunit 2provided by MGI
Primary source: MGI:MGI:1316660
See related: Ensembl:ENSMUSG00000019146 AllianceGenome:MGI:1316660
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: stg; wag; waggler; stargazer; stargazin; B230105C07Rik; B930041E13Rik
Summary: Enables voltage-gated calcium channel activity. Involved in several processes, including neurotransmitter receptor internalization; postsynaptic neurotransmitter receptor diffusion trapping; and protein localization to organelle. Acts upstream of or within several processes, including membrane hyperpolarization; neuromuscular junction development; and transmission of nerve impulse. Located in hippocampal mossy fiber to CA3 synapse and somatodendritic compartment. Is integral component of postsynaptic density membrane. Part of AMPA glutamate receptor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including eye; genitourinary system; ileum; nervous system; and trunk. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 13.3), cortex adult (RPKM 7.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 36.92 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (77876119..78004420, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (77991919..78120220, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TARPgamma2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.
Title: TARPγ2 Is Required for Normal AMPA Receptor Expression and Function in Direction-Selective Circuits of the Mammalian Retina.
Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability.
Title: Aberrant hippocampal transmission and behavior in mice with a stargazin mutation linked to intellectual disability.
AMPAR/TARP stoichiometry differentially modulates channel properties.
Title: AMPAR/TARP stoichiometry differentially modulates channel properties.
GRIP1 regulates synaptic plasticity and learning and memory.
Title: GRIP1 regulates synaptic plasticity and learning and memory.
Proteomic Profile of a Chronic Binge Ethanol Exposure Model.
Title: Proteomic Profile of a Chronic Binge Ethanol Exposure Model.
the entire tail of stargazin (Stg_CT) is required for binding to PSD-95. Stargazin in complex with PSD-95 or PSD-95-assembled postsynaptic complexes form highly concentrated and dynamic condensates via phase separation, reminiscent of stargazin/PSD-95-mediated AMPAR synaptic clustering and trapping.
Title: Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission.
The results from the current study demonstrate that there is an aberrant tissue expression of GABAAR alpha1 and beta2 subunits in the thalamus of PN7-9 juvenile stargazer mice, but that this early change equilibrates during later developmental stages (PN10-12 and PN13-15).
Title: Postnatal expression of thalamic GABAA receptor subunits in the stargazer mouse model of absence epilepsy.
Critically, by altering the two interacting loops of TARP gamma2 and TARP gamma8, the authors could entirely remove all allosteric modulation of GluA2, without affecting formation of AMPA receptor-TARP complexes.
Title: Control of AMPA receptor activity by the extracellular loops of auxiliary proteins.
Learning to cope with stress modulates anterior cingulate cortex stargazin expression in mice.
Title: Learning to cope with stress modulates anterior cingulate cortex stargazin expression in monkeys and mice.
show that upon release of glutamate, synaptic AMPARs were desensitized by transmitter by >90%. As glutamate levels subsequently fell, recovery of transmission occurred due to the presence of the AMPAR accessory protein stargazin that enhances the AMPAR response to low levels of transmitter.
Title: Slow AMPAR Synaptic Transmission Is Determined by Stargazin and Glutamate Transporters.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Spontaneous (3) 1 citation
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cacng2 (e-PCR), detects polymorphism
- UniSTS:498999

AW060990 (e-PCR)
- UniSTS:180794

AF077739 (e-PCR)
- UniSTS:180796

NoName (e-PCR)
- UniSTS:484833

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within membrane depolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within membrane hyperpolarization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor internalization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of AMPA receptor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of AMPA receptor activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmission of nerve impulse	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transmission of nerve impulse	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of AMPA glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AMPA glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of AMPA glutamate receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cerebellar mossy fiber	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
located_in somatodendritic compartment	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: voltage-dependent calcium channel gamma-2 subunit

Names: TARP gamma-2; neuronal voltage-gated calcium channel gamma-2 subunit; transmembrane AMPAR regulatory protein gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007583.2 → NP_031609.1 voltage-dependent calcium channel gamma-2 subunit

See identical proteins and their annotated locations for NP_031609.1

Status: VALIDATED

Source sequence(s)

AL589650, BC103563

Consensus CDS

CCDS27608.1

UniProtKB/Swiss-Prot

O88602

UniProtKB/TrEMBL

Q3ZB20

Related

ENSMUSP00000019290.3, ENSMUST00000019290.3

Conserved Domains (1) summary

pfam00822
Location:6 → 197

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

77876119..78004420 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520371.3 → XP_006520434.1 voltage-dependent calcium channel gamma-2 subunit isoform X1

Conserved Domains (1) summary

cl21598
Location:1 → 174

PMP22_Claudin; PMP-22/EMP/MP20/Claudin family