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Cacnb3 calcium channel, voltage-dependent, beta 3 subunit [ Mus musculus (house mouse) ]

Gene ID: 12297, updated on 3-Apr-2024

Summary

Official Symbol
Cacnb3provided by MGI
Official Full Name
calcium channel, voltage-dependent, beta 3 subunitprovided by MGI
Primary source
MGI:MGI:103307
See related
Ensembl:ENSMUSG00000003352 AllianceGenome:MGI:103307
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CAB3; Beta3; Cchb3; Ca(v)beta3
Summary
Predicted to enable calcium channel regulator activity; high voltage-gated calcium channel activity; and protein kinase binding activity. Acts upstream of or within T cell receptor signaling pathway. Part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human CACNB3 (calcium voltage-gated channel auxiliary subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 57.2), CNS E18 (RPKM 51.8) and 22 other tissues See more
Orthologs
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Genomic context

See Cacnb3 in Genome Data Viewer
Location:
15 F1; 15 54.64 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98526317..98542410)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98628436..98644536)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cyclin T1 Neighboring gene RIKEN cDNA 9330020H09 gene Neighboring gene STARR-positive B cell enhancer ABC_E1917 Neighboring gene sperm microtubule inner protein 11 Neighboring gene adenylate cyclase 6 Neighboring gene STARR-seq mESC enhancer starr_39665 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98440580-98440763 Neighboring gene STARR-positive B cell enhancer ABC_E9921 Neighboring gene STARR-seq mESC enhancer starr_39668 Neighboring gene DEAD box helicase 23 Neighboring gene STARR-positive B cell enhancer ABC_E8612 Neighboring gene STARR-positive B cell enhancer ABC_E9922 Neighboring gene Rho family GTPase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables high voltage-gated calcium channel activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of mechanical stimulus involved in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of detection of mechanical stimulus involved in sensory perception of touch ISO
Inferred from Sequence Orthology
more info
 
involved_in neuromuscular junction development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane hyperpolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane repolarization during action potential ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-dependent L-type calcium channel subunit beta-3
Names
calcium channel voltage-dependent subunit beta 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044741.3NP_001038206.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS37192.1
    UniProtKB/TrEMBL
    D3Z3Z3, Q8K5A7
    Related
    ENSMUSP00000104778.2, ENSMUST00000109150.9
    Conserved Domains (4) summary
    cd12042
    Location:57124
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:175355
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1557
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:185356
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  2. NM_001286226.2NP_001273155.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS88834.1
    UniProtKB/TrEMBL
    A0A2U3TZ49, Q8K5A7
    Related
    ENSMUSP00000003442.9, ENSMUST00000003442.9
    Conserved Domains (4) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:166329
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17190
    Location:165330
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
  3. NM_001356543.2NP_001343472.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC156543
    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:57124
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam12052
    Location:1557
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl27059
    Location:174354
    Guanylate_kin; Guanylate kinase
  4. NM_001410382.1NP_001397311.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC156543
  5. NM_001410383.1NP_001397312.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC156543
  6. NM_001410384.1NP_001397313.1  voltage-dependent L-type calcium channel subunit beta-3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC156543
  7. NM_007581.4NP_031607.2  voltage-dependent L-type calcium channel subunit beta-3 isoform 1

    See identical proteins and their annotated locations for NP_031607.2

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Consensus CDS
    CCDS27800.1
    UniProtKB/Swiss-Prot
    G5E821, P54285
    UniProtKB/TrEMBL
    Q8K5A7
    Related
    ENSMUSP00000155514.2, ENSMUST00000230490.2
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

RNA

  1. NR_177064.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156543
    Related
    ENSMUST00000230064.2
  2. NR_177065.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156543

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98526317..98542410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316418.3XP_017171907.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X10

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:45112
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:163343
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:345
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  2. XM_006520365.2XP_006520428.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X10

    See identical proteins and their annotated locations for XP_006520428.1

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:45112
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:163343
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:345
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  3. XM_036159101.1XP_036014994.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X12

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:45112
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:163343
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:345
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  4. XM_030248302.2XP_030104162.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  5. XM_030248304.2XP_030104164.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  6. XM_006520367.2XP_006520430.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

    See identical proteins and their annotated locations for XP_006520430.1

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  7. XM_017316415.3XP_017171904.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  8. XM_030248303.2XP_030104163.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X1

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  9. XM_036159097.1XP_036014990.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X5

    UniProtKB/Swiss-Prot
    G5E821, P54285
    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:176356
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  10. XM_030248306.2XP_030104166.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  11. XM_036159102.1XP_036014995.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  12. XM_036159104.1XP_036014997.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X14

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  13. XM_036159100.1XP_036014993.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X11

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:49116
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:167347
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:749
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  14. XM_006520361.4XP_006520424.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X3

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:58125
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:175355
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1658
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  15. XM_006520363.4XP_006520426.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X6

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:52119
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:170350
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1052
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  16. XM_006520364.4XP_006520427.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X8

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:49116
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:167347
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:749
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
  17. XM_036159106.1XP_036014999.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X15

    Conserved Domains (1) summary
    pfam00625
    Location:1111
    Guanylate_kin; Guanylate kinase
  18. XM_030248305.2XP_030104165.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X13

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  19. XM_036159103.1XP_036014996.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X14

    Conserved Domains (1) summary
    pfam00625
    Location:1180
    Guanylate_kin; Guanylate kinase
  20. XM_036159099.1XP_036014992.1  voltage-dependent L-type calcium channel subunit beta-3 isoform X9

    UniProtKB/TrEMBL
    Q8K5A7
    Conserved Domains (3) summary
    cd12042
    Location:52119
    SH3_CACNB3; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta3
    pfam00625
    Location:170350
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:1052
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal