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NOXRED1 NADP dependent oxidoreductase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 122945, updated on 25-Jan-2022

Summary

Official Symbol
NOXRED1provided by HGNC
Official Full Name
NADP dependent oxidoreductase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20487
See related
Ensembl:ENSG00000165555 AllianceGenome:HGNC:20487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf148
Summary
Predicted to enable pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in testis (RPKM 2.5), thyroid (RPKM 0.4) and 15 other tissues See more
Orthologs
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Genomic context

See NOXRED1 in Genome Data Viewer
Location:
14q24.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (77394021..77426013, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77860364..77889399, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene transmembrane p24 trafficking protein family member 8 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene sterile alpha motif domain containing 15 Neighboring gene HNF1 motif-containing MPRA enhancer 277 Neighboring gene VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog Neighboring gene activator of HSP90 ATPase activity 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables pyrroline-5-carboxylate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in L-proline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 

General protein information

Preferred Names
NADP-dependent oxidoreductase domain-containing protein 1
Names
pyrroline-5-carboxylate reductase-like protein C14orf148

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113475.3NP_001106946.1  NADP-dependent oxidoreductase domain-containing protein 1

    See identical proteins and their annotated locations for NP_001106946.1

    Status: VALIDATED

    Source sequence(s)
    AC007954, AF111168
    Consensus CDS
    CCDS45142.1
    UniProtKB/Swiss-Prot
    Q6NXP6
    Related
    ENSP00000370215.2, ENST00000380835.7
    Conserved Domains (1) summary
    COG0345
    Location:78189
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
  2. NM_001394980.1NP_001381909.1  NADP-dependent oxidoreductase domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AC007954, AF111168
    Conserved Domains (1) summary
    COG0345
    Location:78189
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    77394021..77426013 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536429.3XP_011534731.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    COG0345
    Location:2999
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
  2. XM_005267330.4XP_005267387.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267387.1

    UniProtKB/Swiss-Prot
    Q6NXP6
    Conserved Domains (1) summary
    COG0345
    Location:78189
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
  3. XM_011536428.3XP_011534730.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011534730.1

    UniProtKB/Swiss-Prot
    Q6NXP6
    Conserved Domains (1) summary
    COG0345
    Location:78189
    ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
  4. XM_017020969.2XP_016876458.1  NADP-dependent oxidoreductase domain-containing protein 1 isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138791.1: Suppressed sequence

    Description
    NM_138791.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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