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Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus (house mouse) ]

Gene ID: 12287, updated on 8-Feb-2024

Summary

Official Symbol
Cacna1bprovided by MGI
Official Full Name
calcium channel, voltage-dependent, N type, alpha 1B subunitprovided by MGI
Primary source
MGI:MGI:88296
See related
Ensembl:ENSMUSG00000004113 AllianceGenome:MGI:88296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIII; Cav2.2; Cchn1a; alpha(1B)
Summary
Enables high voltage-gated calcium channel activity. Acts upstream of or within several processes, including calcium ion transmembrane transport; neurotransmitter secretion; and response to pain. Located in dendrite; membrane; and neuronal cell body. Part of voltage-gated calcium channel complex. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and retina. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 9.4) and 8 other tissues See more
Orthologs
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Genomic context

See Cacna1b in Genome Data Viewer
Location:
2 A3; 2 16.58 cM
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24493872..24653210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24603860..24763200, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Pax8 CNS1 enhancer Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:24603469-24603689 Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:24766046-24766347 Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of calcium-dependent activation of synaptic vesicle fusion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to testosterone ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
voltage-dependent N-type calcium channel subunit alpha-1B
Names
brain calcium channel III
calcium channel, L type, alpha-1 polypeptide
calcium channel, voltage-dependent, L type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII
voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042528.3NP_001035993.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

    See identical proteins and their annotated locations for NP_001035993.1

    Status: VALIDATED

    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS38065.1
    UniProtKB/Swiss-Prot
    O55017, Q60609
    UniProtKB/TrEMBL
    A2AIR7
    Related
    ENSMUSP00000037416.6, ENSMUST00000041342.12
    Conserved Domains (3) summary
    pfam00520
    Location:14811710
    Ion_trans; Ion transport protein
    pfam08763
    Location:17841858
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17181782
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. NM_007579.4NP_031605.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS15739.1
    UniProtKB/TrEMBL
    A2AIR7, A2AIS0
    Related
    ENSMUSP00000063236.8, ENSMUST00000070864.14
    Conserved Domains (3) summary
    pfam00520
    Location:14761707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811819
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17151779
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24493872..24653210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497635.4XP_006497698.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (4) summary
    PHA03307
    Location:18842251
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:94367
    Ion_trans; Ion transport protein
    pfam08763
    Location:17331807
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
  2. XM_006497634.3XP_006497697.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19322299
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9131018
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14581707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17161769
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  3. XM_006497632.3XP_006497695.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

    UniProtKB/TrEMBL
    A2AIR7, A2AIR9
    Related
    ENSMUSP00000100003.3, ENSMUST00000102939.9
    Conserved Domains (5) summary
    PHA03307
    Location:19332300
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9141019
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14591708
    Ion_trans; Ion transport protein
    pfam08763
    Location:17821856
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17171770
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  4. XM_017315156.1XP_017170645.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19522319
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9351040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14801727
    Ion_trans; Ion transport protein
    pfam08763
    Location:18011875
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17361789
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  5. XM_017315140.1XP_017170629.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19582325
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9351040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14841733
    Ion_trans; Ion transport protein
    pfam08763
    Location:18071881
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17421795
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  6. XM_017315146.1XP_017170635.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19372304
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9141019
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14631712
    Ion_trans; Ion transport protein
    pfam08763
    Location:17861860
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17211774
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  7. XM_006497633.3XP_006497696.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19322299
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9151020
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14601707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17161769
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  8. XM_006497631.3XP_006497694.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19382305
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9151020
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14641713
    Ion_trans; Ion transport protein
    pfam08763
    Location:17871861
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17221775
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  9. XM_006497629.3XP_006497692.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19542321
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9351040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14801729
    Ion_trans; Ion transport protein
    pfam08763
    Location:18031877
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17381791
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  10. XM_006497627.3XP_006497690.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19582325
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9351040
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14841733
    Ion_trans; Ion transport protein
    pfam08763
    Location:18071881
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17421795
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  11. XM_006497630.3XP_006497693.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19532320
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14811728
    Ion_trans; Ion transport protein
    pfam08763
    Location:18021876
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17371790
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  12. XM_006497628.3XP_006497691.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19552322
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14811730
    Ion_trans; Ion transport protein
    pfam08763
    Location:18041878
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17391792
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  13. XM_017315141.1XP_017170630.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19572324
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14851732
    Ion_trans; Ion transport protein
    pfam08763
    Location:18061880
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17411794
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  14. XM_006497626.3XP_006497689.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

    UniProtKB/TrEMBL
    A2AIR7
    Conserved Domains (5) summary
    PHA03307
    Location:19592326
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14851734
    Ion_trans; Ion transport protein
    pfam08763
    Location:18081882
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17431796
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  15. XM_011239014.2XP_011237316.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

    UniProtKB/TrEMBL
    Q3UYN6
    Conserved Domains (4) summary
    PHA03307
    Location:8501217
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:376625
    Ion_trans; Ion transport protein
    pfam08763
    Location:699773
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:634687
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  16. XM_006497637.5XP_006497700.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

    Conserved Domains (3) summary
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14851734
    Ion_trans; Ion transport protein
    pfam16905
    Location:17431756
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  17. XM_017315155.2XP_017170644.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

    Conserved Domains (3) summary
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14811728
    Ion_trans; Ion transport protein
    pfam16905
    Location:17371782
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  18. XM_006497638.4XP_006497701.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

    Conserved Domains (3) summary
    pfam01271
    Location:9361041
    Granin; Granin (chromogranin or secretogranin)
    pfam00520
    Location:14851734
    Ion_trans; Ion transport protein
    pfam16905
    Location:17431788
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RNA

  1. XR_003950091.2 RNA Sequence

  2. XR_374052.4 RNA Sequence