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Cacna1b calcium channel, voltage-dependent, N type, alpha 1B subunit [ Mus musculus (house mouse) ]

Gene ID: 12287, updated on 12-Aug-2019

Summary

Official Symbol
Cacna1bprovided by MGI
Official Full Name
calcium channel, voltage-dependent, N type, alpha 1B subunitprovided by MGI
Primary source
MGI:MGI:88296
See related
Ensembl:ENSMUSG00000004113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BIII; Cav2.2; Cchn1a; AW050276; AW060892; AW822256; alpha(1B)
Expression
Biased expression in CNS E18 (RPKM 11.3), whole brain E14.5 (RPKM 9.4) and 8 other tissues See more
Orthologs

Genomic context

See Cacna1b in Genome Data Viewer
Location:
2 A3; 2 16.58 cM
Exon count:
52
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24603860..24763200, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (24461895..24618672, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39769 Neighboring gene Pax8 CNS87 enhancer Neighboring gene WW domain containing E3 ubiquitin protein ligase 1 pseudogene Neighboring gene euchromatic histone methyltransferase 1 Neighboring gene arrestin domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystem (from REACTOME)
    Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • GABAergic synapse, organism-specific biosystem (from KEGG)
    GABAergic synapse, organism-specific biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
  • GABAergic synapse, conserved biosystem (from KEGG)
    GABAergic synapse, conserved biosystemGamma aminobutyric acid (GABA) is the most abundant inhibitory neurotransmitter in the mammalian central nervous system (CNS). When released in the synaptic cleft, GABA binds to three major classes o...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Neuronal System, organism-specific biosystem (from REACTOME)
    Neuronal System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Nicotine addiction, organism-specific biosystem (from KEGG)
    Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Nicotine addiction, conserved biosystem (from KEGG)
    Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
  • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
    Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
    Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
    Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Synaptic vesicle cycle, conserved biosystem (from KEGG)
    Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
  • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
    Transmission across Chemical Synapses, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase 2A binding ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels ISO
Inferred from Sequence Orthology
more info
 
voltage-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion import ISO
Inferred from Sequence Orthology
more info
 
calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neurotransmitter secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to testosterone ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
axon terminus ISO
Inferred from Sequence Orthology
more info
 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
voltage-dependent N-type calcium channel subunit alpha-1B
Names
brain calcium channel III
calcium channel, L type, alpha-1 polypeptide
calcium channel, voltage-dependent, L type, alpha 1B subunit
calcium channel, voltage-dependent, N type, alpha 1B subunit, BIII
voltage-gated calcium channel subunit alpha Cav2.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042528.2NP_001035993.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform 1

    See identical proteins and their annotated locations for NP_001035993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS38065.1
    UniProtKB/Swiss-Prot
    O55017
    Related
    ENSMUSP00000037416.5, ENSMUST00000041342.11
    Conserved Domains (3) summary
    pfam00520
    Location:14811710
    Ion_trans; Ion transport protein
    pfam08763
    Location:17841858
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17181782
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. NM_007579.3NP_031605.2  voltage-dependent N-type calcium channel subunit alpha-1B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AL732525, AL732546, BX294112
    Consensus CDS
    CCDS15739.1
    UniProtKB/TrEMBL
    A2AIS0
    Related
    ENSMUSP00000063236.7, ENSMUST00000070864.13
    Conserved Domains (3) summary
    pfam00520
    Location:14761707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811819
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17151779
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p6 C57BL/6J

    Range
    24603860..24763200 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497634.3XP_006497697.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X12

    Conserved Domains (3) summary
    pfam00520
    Location:14761707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17151779
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. XM_006497632.3XP_006497695.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X10

    UniProtKB/TrEMBL
    A2AIR9
    Related
    ENSMUSP00000100003.2, ENSMUST00000102939.8
    Conserved Domains (3) summary
    pfam00520
    Location:14771708
    Ion_trans; Ion transport protein
    pfam08763
    Location:17821856
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17161780
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  3. XM_017315156.1XP_017170645.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X20

  4. XM_017315140.1XP_017170629.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X3

  5. XM_017315146.1XP_017170635.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X9

  6. XM_006497633.3XP_006497696.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X11

    Conserved Domains (3) summary
    pfam00520
    Location:14781707
    Ion_trans; Ion transport protein
    pfam08763
    Location:17811855
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17151779
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  7. XM_006497631.3XP_006497694.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X8

    Conserved Domains (3) summary
    pfam00520
    Location:14821713
    Ion_trans; Ion transport protein
    pfam08763
    Location:17871861
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17211785
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  8. XM_006497629.3XP_006497692.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X6

    Conserved Domains (3) summary
    pfam00520
    Location:14981729
    Ion_trans; Ion transport protein
    pfam08763
    Location:18031877
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17371801
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  9. XM_006497627.3XP_006497690.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X2

    Conserved Domains (3) summary
    pfam00520
    Location:15021733
    Ion_trans; Ion transport protein
    pfam08763
    Location:18071881
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17411805
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  10. XM_006497630.3XP_006497693.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X7

    Conserved Domains (3) summary
    pfam00520
    Location:14991728
    Ion_trans; Ion transport protein
    pfam08763
    Location:18021876
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17361800
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  11. XM_006497628.3XP_006497691.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X5

    Conserved Domains (3) summary
    pfam00520
    Location:14991730
    Ion_trans; Ion transport protein
    pfam08763
    Location:18041878
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17381802
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  12. XM_017315141.1XP_017170630.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X4

  13. XM_006497635.3XP_006497698.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X13

    Conserved Domains (3) summary
    pfam00520
    Location:15031722
    Ion_trans; Ion transport protein
    pfam08763
    Location:17331807
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17141731
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  14. XM_006497626.3XP_006497689.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1

    Conserved Domains (3) summary
    pfam00520
    Location:15031734
    Ion_trans; Ion transport protein
    pfam08763
    Location:18081882
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17421806
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  15. XM_006497636.4XP_006497699.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X14

    Conserved Domains (3) summary
    pfam00520
    Location:13751606
    Ion_trans; Ion transport protein
    pfam08763
    Location:16801754
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:16141678
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  16. XM_011239014.1XP_011237316.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X19

    Conserved Domains (3) summary
    pfam00520
    Location:394625
    Ion_trans; Ion transport protein
    pfam08763
    Location:699773
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:633697
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  17. XM_006497637.4XP_006497700.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X15

    Conserved Domains (2) summary
    pfam00520
    Location:15031734
    Ion_trans; Ion transport protein
    pfam16905
    Location:17421756
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  18. XM_017315155.1XP_017170644.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X17

  19. XM_006497638.3XP_006497701.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X16

    Conserved Domains (2) summary
    pfam00520
    Location:15031734
    Ion_trans; Ion transport protein
    pfam16905
    Location:17421788
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  20. XM_006497640.3XP_006497703.1  voltage-dependent N-type calcium channel subunit alpha-1B isoform X18

    Conserved Domains (1) summary
    pfam00520
    Location:112367
    Ion_trans; Ion transport protein

RNA

  1. XR_003950091.1 RNA Sequence

  2. XR_374052.3 RNA Sequence

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