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Cacna1a calcium channel, voltage-dependent, P/Q type, alpha 1A subunit [ Mus musculus (house mouse) ]

Gene ID: 12286, updated on 5-Mar-2024

Summary

Official Symbol
Cacna1aprovided by MGI
Official Full Name
calcium channel, voltage-dependent, P/Q type, alpha 1A subunitprovided by MGI
Primary source
MGI:MGI:109482
See related
Ensembl:ENSMUSG00000034656 AllianceGenome:MGI:109482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BI; la; tg; EA2; FHM; MHP; rkr; APCA; HPCA; MHP1; SCA6; smrl; Caca1a; Cav2.1; Ccha1a; nmf352; alpha1A; Cacnl1a4
Summary
Enables high voltage-gated calcium channel activity and voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels. Acts upstream of or within several processes, including cellular ion homeostasis; chemical synaptic transmission; and nervous system development. Located in dendrite and neuronal cell body. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; heart; and trigeminal nerve. Used to study Lambert-Eaton myasthenic syndrome; brain disease (multiple); and episodic ataxia type 2. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 34.5), cortex adult (RPKM 15.3) and 11 other tissues See more
Orthologs
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Genomic context

See Cacna1a in Genome Data Viewer
Location:
8 C2- C3; 8 40.95 cM
Exon count:
53
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85065257..85366880)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84338631..84640251)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E297 Neighboring gene STARR-positive B cell enhancer ABC_E10514 Neighboring gene STARR-positive B cell enhancer mm9_chr8:86815694-86815995 Neighboring gene YJU2 splicing factor homolog B Neighboring gene THO complex 6 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_22121 Neighboring gene STARR-seq mESC enhancer starr_22122 Neighboring gene predicted gene, 23626 Neighboring gene STARR-seq mESC enhancer starr_22125 Neighboring gene STARR-seq mESC enhancer starr_22126 Neighboring gene predicted gene, 32854 Neighboring gene predicted gene 16183 Neighboring gene STARR-seq mESC enhancer starr_22132 Neighboring gene STARR-seq mESC enhancer starr_22133 Neighboring gene STARR-seq mESC enhancer starr_22134 Neighboring gene STARR-positive B cell enhancer ABC_E5025 Neighboring gene predicted gene, 39212 Neighboring gene predicted gene, 39211 Neighboring gene immediate early response 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables high voltage-gated calcium channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables high voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
Inferred from Direct Assay
more info
PubMed 
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adult walking behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adult walking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium-ion regulated exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within central nervous system neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellar molecular layer development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cerebellum maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of localization in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular chloride ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within musculoskeletal movement, spinal reflex action IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of hormone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nervous system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within receptor clustering IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of acetylcholine secretion, neurotransmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of hormone levels IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of sulfur amino acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within synaptic transmission, GABAergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vestibular nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
voltage-dependent P/Q-type calcium channel subunit alpha-1A
Names
brain calcium channel I
calcium channel, L type, alpha-1 polypeptide
leaner
rocker
tottering
voltage-gated calcium channel subunit alpha Cav2.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252059.1NP_001238988.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC145556, AC164557, AK147277, AK147288, AU254963, AV375776
    Consensus CDS
    CCDS57628.1
    UniProtKB/TrEMBL
    E9Q1R5, Q3UHA5
    Related
    ENSMUSP00000114055.2, ENSMUST00000122053.2
    Conserved Domains (6) summary
    pfam00520
    Location:14871726
    Ion_trans; Ion transport protein
    pfam01254
    Location:21412200
    TP2; Nuclear transition protein 2
    pfam08763
    Location:17991873
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10243
    Location:6881001
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12300
    Location:22242308
    DUF3628; Protein of unknown function (DUF3628)
    pfam16905
    Location:17341797
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  2. NM_001252060.1NP_001238989.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 3' coding region which results in a frameshift, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB066608, AC145556, AC164557, AK147288, AV375776
    UniProtKB/TrEMBL
    Q8R5M7
    Conserved Domains (5) summary
    pfam00520
    Location:15341773
    Ion_trans; Ion transport protein
    pfam01254
    Location:21882256
    TP2; Nuclear transition protein 2
    pfam08763
    Location:18461920
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10243
    Location:7351048
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam16905
    Location:17811844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  3. NM_001252061.1NP_001238990.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 4, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB066609, AC145556, AC164557, AK147288, AV375776
    UniProtKB/TrEMBL
    Q8R5M6
    Conserved Domains (3) summary
    pfam00520
    Location:15341773
    Ion_trans; Ion transport protein
    pfam08763
    Location:18461920
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:17811844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  4. NM_007578.3NP_031604.3  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform 1

    See identical proteins and their annotated locations for NP_031604.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AK147288, AK147498, AV375776
    Consensus CDS
    CCDS52618.1
    UniProtKB/Swiss-Prot
    P97445, Q2TPN3
    UniProtKB/TrEMBL
    Q3UHN4
    Related
    ENSMUSP00000112436.2, ENSMUST00000121390.8
    Conserved Domains (6) summary
    pfam00520
    Location:15341773
    Ion_trans; Ion transport protein
    pfam01254
    Location:21882247
    TP2; Nuclear transition protein 2
    pfam08763
    Location:18461920
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam10243
    Location:7351048
    MIP-T3; Microtubule-binding protein MIP-T3
    pfam12300
    Location:22712355
    DUF3628; Protein of unknown function (DUF3628)
    pfam16905
    Location:17811844
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85065257..85366880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530609.4XP_006530672.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X24

    See identical proteins and their annotated locations for XP_006530672.1

    Conserved Domains (2) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:188462
    Ion_trans; Ion transport protein
  2. XM_036153733.1XP_036009626.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X24

    Conserved Domains (2) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:188462
    Ion_trans; Ion transport protein
  3. XM_006530605.5XP_006530668.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X23

    Conserved Domains (2) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
  4. XM_006530587.5XP_006530650.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20462460
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  5. XM_011248285.4XP_011246587.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X19

    UniProtKB/TrEMBL
    Q8R5M7
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam01254
    Location:22842343
    TP2; Nuclear transition protein 2
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  6. XM_006530603.5XP_006530666.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X20

    UniProtKB/TrEMBL
    Q8R5M7
    Conserved Domains (4) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  7. XM_006530601.5XP_006530664.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X15

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20462448
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  8. XM_030243261.2XP_030099121.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X21

    UniProtKB/TrEMBL
    Q8R5M7
    Conserved Domains (4) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  9. XM_006530588.5XP_006530651.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X2

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20462460
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  10. XM_036153732.1XP_036009625.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X16

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20462448
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  11. XM_030243262.2XP_030099122.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X22

    UniProtKB/TrEMBL
    Q8R5M7
    Conserved Domains (4) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    pfam00520
    Location:16101869
    Ion_trans; Ion transport protein
    pfam08763
    Location:19422015
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18781931
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  12. XM_006530592.5XP_006530655.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X6

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20442458
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101867
    Ion_trans; Ion transport protein
    pfam08763
    Location:19402013
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18761929
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  13. XM_006530593.5XP_006530656.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X7

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20442458
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16101867
    Ion_trans; Ion transport protein
    pfam08763
    Location:19402013
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18761929
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  14. XM_006530602.4XP_006530665.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X18

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20162430
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:188462
    Ion_trans; Ion transport protein
    pfam08763
    Location:19121985
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18481901
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  15. XM_006530595.5XP_006530658.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X9

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20422456
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16061865
    Ion_trans; Ion transport protein
    pfam08763
    Location:19382011
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18741927
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  16. XM_006530596.5XP_006530659.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X10

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20422456
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16061865
    Ion_trans; Ion transport protein
    pfam08763
    Location:19382011
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18741927
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  17. XM_006530598.5XP_006530661.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X12

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20402454
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16061863
    Ion_trans; Ion transport protein
    pfam08763
    Location:19362009
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18721925
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  18. XM_006530589.5XP_006530652.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X3

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8941276
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20452459
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16091868
    Ion_trans; Ion transport protein
    pfam08763
    Location:19412014
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18771930
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  19. XM_006530591.5XP_006530654.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X5

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8931275
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20442458
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16081867
    Ion_trans; Ion transport protein
    pfam08763
    Location:19402013
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18761929
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  20. XM_006530600.5XP_006530663.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X14

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8931275
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20382452
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16041861
    Ion_trans; Ion transport protein
    pfam08763
    Location:19342007
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18701923
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  21. XM_006530590.5XP_006530653.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X4

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8941276
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20452459
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16091868
    Ion_trans; Ion transport protein
    pfam08763
    Location:19412014
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18771930
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  22. XM_006530594.5XP_006530657.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X8

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8921274
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20432457
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16071866
    Ion_trans; Ion transport protein
    pfam08763
    Location:19392012
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18751928
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  23. XM_006530599.5XP_006530662.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X13

    UniProtKB/TrEMBL
    A0A571BET0, Q3UHN4
    Related
    ENSMUSP00000158803.2, ENSMUST00000238701.2
    Conserved Domains (5) summary
    PHA03247
    Location:8941276
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20392453
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16051862
    Ion_trans; Ion transport protein
    pfam08763
    Location:19352008
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18711924
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  24. XM_030243260.2XP_030099120.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X17

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20402442
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16061863
    Ion_trans; Ion transport protein
    pfam08763
    Location:19362009
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18721925
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated
  25. XM_006530597.5XP_006530660.1  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X11

    UniProtKB/TrEMBL
    Q3UHN4
    Conserved Domains (5) summary
    PHA03247
    Location:8951277
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:20402454
    PHA03307; transcriptional regulator ICP4; Provisional
    pfam00520
    Location:16061863
    Ion_trans; Ion transport protein
    pfam08763
    Location:19362009
    Ca_chan_IQ; Voltage gated calcium channel IQ domain
    pfam16905
    Location:18721925
    GPHH; Voltage-dependent L-type calcium channel, IQ-associated

RNA

  1. XR_003947223.2 RNA Sequence

  2. XR_003947224.2 RNA Sequence

  3. XR_003947227.2 RNA Sequence

  4. XR_004934753.1 RNA Sequence

  5. XR_003947226.2 RNA Sequence

  6. XR_003947222.2 RNA Sequence

  7. XR_003947221.2 RNA Sequence