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SOCS4 suppressor of cytokine signaling 4 [ Homo sapiens (human) ]

Gene ID: 122809, updated on 21-Dec-2019

Summary

Official Symbol
SOCS4provided by HGNC
Official Full Name
suppressor of cytokine signaling 4provided by HGNC
Primary source
HGNC:HGNC:19392
See related
Ensembl:ENSG00000180008 MIM:616337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SOCS7
Summary
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 5.4), lymph node (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See SOCS4 in Genome Data Viewer
Location:
14q22.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (55027131..55049489)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55493844..55516207)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2393 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene ribosomal protein SA pseudogene 13 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1 like Neighboring gene Sharpr-MPRA regulatory region 8345

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686J1568

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphatidylinositol 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
phosphatidylinositol 3-kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
suppressor of cytokine signaling 4
Names
SH2 domain containing SOCS box protein
SOCS-4
SOCS-7
suppressor of cytokine signaling 7

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080867.3NP_543143.1  suppressor of cytokine signaling 4

    See identical proteins and their annotated locations for NP_543143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' region, as compared to variant 1.
    Source sequence(s)
    AK126195, BC060790, BX161418, BX648734
    Consensus CDS
    CCDS9722.1
    UniProtKB/Swiss-Prot
    Q8WXH5
    UniProtKB/TrEMBL
    Q5H9R6
    Related
    ENSP00000378855.2, ENST00000395472.2
    Conserved Domains (3) summary
    cd10385
    Location:275375
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:384439
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:59111
    SOCS; Suppressor of cytokine signalling
  2. NM_199421.2NP_955453.1  suppressor of cytokine signaling 4

    See identical proteins and their annotated locations for NP_955453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and it has an additional exon in the 5' region.
    Source sequence(s)
    AK126195, BC060790, BX648734, CD109883
    Consensus CDS
    CCDS9722.1
    UniProtKB/Swiss-Prot
    Q8WXH5
    UniProtKB/TrEMBL
    Q5H9R6
    Related
    ENSP00000452522.1, ENST00000555846.2
    Conserved Domains (3) summary
    cd10385
    Location:275375
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:384439
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:59111
    SOCS; Suppressor of cytokine signalling

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    55027131..55049489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536425.1XP_011534727.1  suppressor of cytokine signaling 4 isoform X1

    See identical proteins and their annotated locations for XP_011534727.1

    UniProtKB/Swiss-Prot
    Q8WXH5
    UniProtKB/TrEMBL
    Q5H9R6
    Conserved Domains (3) summary
    cd10385
    Location:275375
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:384439
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:59111
    SOCS; Suppressor of cytokine signalling
  2. XM_011536426.1XP_011534728.1  suppressor of cytokine signaling 4 isoform X1

    See identical proteins and their annotated locations for XP_011534728.1

    UniProtKB/Swiss-Prot
    Q8WXH5
    UniProtKB/TrEMBL
    Q5H9R6
    Conserved Domains (3) summary
    cd10385
    Location:275375
    SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03738
    Location:384439
    SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
    pfam12610
    Location:59111
    SOCS; Suppressor of cytokine signalling
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