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C1qbp complement component 1, q subcomponent binding protein [ Mus musculus (house mouse) ]

Gene ID: 12261, updated on 8-Nov-2022

Summary

Official Symbol
C1qbpprovided by MGI
Official Full Name
complement component 1, q subcomponent binding proteinprovided by MGI
Primary source
MGI:MGI:1194505
See related
Ensembl:ENSMUSG00000018446 AllianceGenome:MGI:1194505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P32; HABP1; gC1qBP; D11Wsu182e
Summary
Enables mRNA binding activity and mitochondrial ribosome binding activity. Involved in mature ribosome assembly and positive regulation of mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including alimentary system; axial musculature; brain ventricular layer; genitourinary system; and orbito-sphenoid. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 33. Orthologous to human C1QBP (complement C1q binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal adult (RPKM 411.1), stomach adult (RPKM 150.3) and 24 other tissues See more
Orthologs
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Genomic context

See C1qbp in Genome Data Viewer
Location:
11 B4; 11 43.21 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70868672..70873852, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70977846..70983026, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene rabaptin, RAB GTPase binding effector protein 1 Neighboring gene predicted gene 12322 Neighboring gene nucleoporin 88 Neighboring gene RPA interacting protein Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 33 Neighboring gene predicted gene, 22297 Neighboring gene Der1-like domain family, member 2 Neighboring gene MIS12 kinetochore complex component

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables complement component C1q complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement component C1q complex binding ISO
Inferred from Sequence Orthology
more info
 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables kininogen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables kininogen binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitochondrial ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cytosolic ribosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytosolic ribosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytosolic ribosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of complement activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of complement activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement component 1 Q subcomponent-binding protein, mitochondrial
Names
GC1q-R protein
glycoprotein gC1qBP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007573.2NP_031599.2  complement component 1 Q subcomponent-binding protein, mitochondrial

    See identical proteins and their annotated locations for NP_031599.2

    Status: VALIDATED

    Source sequence(s)
    AK010601, BY275303, CF381952
    Consensus CDS
    CCDS24970.1
    UniProtKB/TrEMBL
    A0A8C6I083, Q8R5L1
    Related
    ENSMUSP00000077612.7, ENSMUST00000078528.7
    Conserved Domains (1) summary
    pfam02330
    Location:87270
    MAM33; Mitochondrial glycoprotein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    70868672..70873852 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)