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Bub1 BUB1, mitotic checkpoint serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 12235, updated on 4-Nov-2022

Summary

Official Symbol
Bub1provided by MGI
Official Full Name
BUB1, mitotic checkpoint serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1100510
See related
Ensembl:ENSMUSG00000027379 AllianceGenome:MGI:1100510
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bub1a; D2Xrf87
Summary
Predicted to enable protein kinase activity. Acts upstream of or within chromosome segregation and positive regulation of intrinsic apoptotic signaling pathway. Located in kinetochore. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 13.2), liver E14 (RPKM 9.4) and 10 other tissues See more
Orthologs
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Genomic context

See Bub1 in Genome Data Viewer
Location:
2 F1; 2 62.1 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127642117..127673790, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127800197..127831859, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nephronophthisis 1 (juvenile) homolog (human) Neighboring gene mitoregulin Neighboring gene acyl-Coenzyme A oxidase-like Neighboring gene predicted gene, 23101 Neighboring gene BCL2-like 11 (apoptosis facilitator)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in condensed chromosome, centromeric region IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitotic checkpoint serine/threonine-protein kinase BUB1
Names
budding uninhibited by benzimidazoles 1 homolog
mBUB1
NP_001106650.1
NP_033902.2
XP_006498683.1
XP_036013667.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113179.1NP_001106650.1  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK042932, AK144213, AL844204, U89795
    Consensus CDS
    CCDS50706.1
    UniProtKB/Swiss-Prot
    O08901
    UniProtKB/TrEMBL
    A2APR8, Q8K1K8
    Related
    ENSMUSP00000028858.8, ENSMUST00000028858.9
    Conserved Domains (2) summary
    pfam08311
    Location:6125
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7611047
    PKc_like; Protein Kinases, catalytic domain
  2. NM_009772.2NP_033902.2  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the mid-coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK042932, AL844204, U89795
    UniProtKB/Swiss-Prot
    O08901
    UniProtKB/TrEMBL
    A0A8I4YXJ8
    Related
    ENSMUSP00001091667.1, ENSMUST00020183811.1
    Conserved Domains (2) summary
    pfam08311
    Location:6125
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7601046
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127642117..127673790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157774.1XP_036013667.1  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X2

    Conserved Domains (2) summary
    pfam08311
    Location:9125
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7461032
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006498620.4XP_006498683.1  mitotic checkpoint serine/threonine-protein kinase BUB1 isoform X1

    Conserved Domains (2) summary
    pfam08311
    Location:9125
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7471033
    PKc_like; Protein Kinases, catalytic domain