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Bpgm 2,3-bisphosphoglycerate mutase [ Mus musculus (house mouse) ]

Gene ID: 12183, updated on 23-Mar-2024

Summary

Official Symbol
Bpgmprovided by MGI
Official Full Name
2,3-bisphosphoglycerate mutaseprovided by MGI
Primary source
MGI:MGI:1098242
See related
Ensembl:ENSMUSG00000038871 AllianceGenome:MGI:1098242
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable bisphosphoglycerate mutase activity; hydrolase activity; and phosphoglycerate mutase activity. Predicted to be involved in glycolytic process. Is expressed in alimentary system; early conceptus; liver; oocyte; and respiratory system. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 75.5), liver E14.5 (RPKM 74.5) and 24 other tissues See more
Orthologs
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Genomic context

See Bpgm in Genome Data Viewer
Location:
6 B1; 6 15.01 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34453291..34482071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34476356..34505136)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene aldo-keto reductase family 1, member B7 Neighboring gene aldo-keto reductase family 1, member B7 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:34426033-34426334 Neighboring gene predicted gene, 52898 Neighboring gene predicted gene, 32942

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
Inferred from Electronic Annotation
more info
 
enables bisphosphoglycerate mutase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
bisphosphoglycerate mutase
Names
2,3-bisphosphoglycerate mutase, erythrocyte
2,3-bisphosphoglycerate synthase
BPG-dependent PGAM
NP_001350637.1
NP_001350638.1
NP_001350639.1
NP_031589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363708.1NP_001350637.1  bisphosphoglycerate mutase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC115767
    Conserved Domains (1) summary
    cl11399
    Location:4116
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  2. NM_001363709.1NP_001350638.1  bisphosphoglycerate mutase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115767
    Conserved Domains (1) summary
    cl11399
    Location:1153
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  3. NM_001363710.1NP_001350639.1  bisphosphoglycerate mutase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC115767
    Conserved Domains (1) summary
    cl11399
    Location:1153
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
  4. NM_007563.5NP_031589.1  bisphosphoglycerate mutase isoform 1

    See identical proteins and their annotated locations for NP_031589.1

    Status: VALIDATED

    Source sequence(s)
    AC115767
    Consensus CDS
    CCDS19994.1
    UniProtKB/Swiss-Prot
    P15327, Q543Z6
    UniProtKB/TrEMBL
    Q3TAQ8
    Related
    ENSMUSP00000047393.6, ENSMUST00000045372.6
    Conserved Domains (1) summary
    cl11399
    Location:4255
    HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction

RNA

  1. NR_156731.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC115767

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34453291..34482071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)