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Bmx BMX non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 12169, updated on 8-Feb-2024

Summary

Official Symbol
Bmxprovided by MGI
Official Full Name
BMX non-receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1101778
See related
Ensembl:ENSMUSG00000031377 AllianceGenome:MGI:1101778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etk; Tyro8; Etk/Bmx
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and peptidyl-tyrosine autophosphorylation. Predicted to act upstream of or within apoptotic process; cell adhesion; and phosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Is expressed in several structures, including cardiovascular system; central nervous system; immune system; lung; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 1.1), lung adult (RPKM 0.9) and 22 other tissues See more
Orthologs
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Genomic context

See Bmx in Genome Data Viewer
Location:
X F5; X 76.12 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (162975838..163041189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (164192842..164258193, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene collectrin, amino acid transport regulator Neighboring gene STARR-seq mESC enhancer starr_48236 Neighboring gene angiotensin converting enzyme 2 Neighboring gene predicted gene, 19251 Neighboring gene STARR-seq mESC enhancer starr_48237 Neighboring gene predicted gene, 46692 Neighboring gene predicted gene, 57673 Neighboring gene pirin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoplasmic tyrosine-protein kinase BMX
Names
TYRO8 protein tyrosine kinase 8
bone marrow tyrosine kinase gene in chromosome X protein homolog
NP_033889.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009759.4NP_033889.2  cytoplasmic tyrosine-protein kinase BMX

    Status: VALIDATED

    Source sequence(s)
    AK036707, AK040936
    Consensus CDS
    CCDS30519.2
    UniProtKB/Swiss-Prot
    P97504
    UniProtKB/TrEMBL
    B1AUL5, B1AUL6
    Related
    ENSMUSP00000107884.3, ENSMUST00000112265.9
    Conserved Domains (5) summary
    cd10399
    Location:269374
    SH2_Tec_Bmx; Src homology 2 (SH2) domain found in Tec protein, Bmx
    cd01238
    Location:25151
    PH_Btk; Bruton's tyrosine kinase pleckstrin homology (PH) domain
    pfam00169
    Location:27115
    PH; PH domain
    pfam07714
    Location:397646
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:392647
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    162975838..163041189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)