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Bmp5 bone morphogenetic protein 5 [ Mus musculus (house mouse) ]

Gene ID: 12160, updated on 5-Jun-2018
Official Symbol
Bmp5provided by MGI
Official Full Name
bone morphogenetic protein 5provided by MGI
Primary source
MGI:MGI:88181
See related
Ensembl:ENSMUSG00000032179 Vega:OTTMUSG00000021529
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
se; AU023399
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]
Expression
Biased expression in bladder adult (RPKM 8.5), lung adult (RPKM 3.4) and 10 other tissues See more
Orthologs
See Bmp5 in Genome Data Viewer
Location:
9 D; 9 42.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (75775365..75900316)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (75623172..75746824)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 39373 Neighboring gene predicted gene, 34005 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • BMP signaling, organism-specific biosystem (from KEGG)
    BMP signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • BMP signaling, conserved biosystem (from KEGG)
    BMP signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
    TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
  • TGF-beta signaling pathway, conserved biosystem (from KEGG)
    TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
BMP receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
allantois development IGI
Inferred from Genetic Interaction
more info
PubMed 
anterior head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
cardiac septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
cartilage development IEA
Inferred from Electronic Annotation
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
chorio-allantoic fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
heart trabecula morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
male genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
neural fold elevation formation IGI
Inferred from Genetic Interaction
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
pericardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
bone morphogenetic protein 5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007555.4NP_031581.2  bone morphogenetic protein 5 preproprotein

    See identical proteins and their annotated locations for NP_031581.2

    Status: REVIEWED

    Source sequence(s)
    AC079245, AK033362, AK135704
    Consensus CDS
    CCDS23348.1
    UniProtKB/Swiss-Prot
    P49003
    UniProtKB/TrEMBL
    Q3UXE6
    Related
    ENSMUSP00000012281.7, OTTMUSP00000023977, ENSMUST00000012281.7, OTTMUST00000051064
    Conserved Domains (2) summary
    pfam00019
    Location:351453
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:31304
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    75775365..75900316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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