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Bmp5 bone morphogenetic protein 5 [ Mus musculus (house mouse) ]

Gene ID: 12160, updated on 18-Apr-2024

Summary

Official Symbol
Bmp5provided by MGI
Official Full Name
bone morphogenetic protein 5provided by MGI
Primary source
MGI:MGI:88181
See related
Ensembl:ENSMUSG00000032179 AllianceGenome:MGI:88181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
se
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Mice with null mutations in this gene exhibit a short ear phenotype, which is characterized by reduced size of the external ear, altered size and shape of the sternum, and other skeletal and soft-tissue abnormalities. [provided by RefSeq, Jul 2016]
Expression
Biased expression in bladder adult (RPKM 8.5), lung adult (RPKM 3.4) and 10 other tissues See more
Orthologs
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Genomic context

Location:
9 D; 9 42.34 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (75682647..75807598)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75775365..75900316)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_24674 Neighboring gene STARR-seq mESC enhancer starr_24675 Neighboring gene predicted gene, 39373 Neighboring gene Ex4r enhancer intronic to Bmp5 Neighboring gene STARR-seq mESC enhancer starr_24676 Neighboring gene predicted gene, 34005 Neighboring gene STARR-positive B cell enhancer mm9_chr9:75851566-75851867 Neighboring gene STARR-seq mESC enhancer starr_24677 Neighboring gene 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase-like 1 Neighboring gene STARR-seq mESC enhancer starr_24678 Neighboring gene STARR-seq mESC enhancer starr_24679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Chemically induced (ENU) (1) 
  • Spontaneous (6)  1 citation
  • Chemically induced (other) (2)  1 citation
  • Radiation induced (15)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in allantois development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within anterior head development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cardiac septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in chorio-allantoic fusion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endocardial cushion formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heart trabecula morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within male genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of aldosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cortisol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neural fold elevation formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pericardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in pharyngeal system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in type B pancreatic cell development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bone morphogenetic protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007555.4NP_031581.2  bone morphogenetic protein 5 preproprotein

    See identical proteins and their annotated locations for NP_031581.2

    Status: REVIEWED

    Source sequence(s)
    AC079245, AK033362, AK135704
    Consensus CDS
    CCDS23348.1
    UniProtKB/TrEMBL
    Q496P8
    Related
    ENSMUSP00000012281.8, ENSMUST00000012281.8
    Conserved Domains (2) summary
    pfam00019
    Location:351453
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:31304
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    75682647..75807598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)