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Bmp10 bone morphogenetic protein 10 [ Mus musculus (house mouse) ]

Gene ID: 12154, updated on 4-Dec-2019

Summary

Official Symbol
Bmp10provided by MGI
Official Full Name
bone morphogenetic protein 10provided by MGI
Primary source
MGI:MGI:1338820
See related
Ensembl:ENSMUSG00000030046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
b2b2711Clo
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which binds to the activin receptor-like kinase 1 (ALK1) and plays important roles in cardiovascular development including cardiomyocyte proliferation and regulation of heart size, closure of the ductus arteriosus, angiogenesis and ventricular trabeculation. Homozygous knockout mice for this gene exhibit impaired heart development and embryonic lethality. [provided by RefSeq, Aug 2016]
Expression
Biased expression in heart adult (RPKM 23.3) and liver E18 (RPKM 1.3) See more
Orthologs

Genomic context

See Bmp10 in Genome Data Viewer
Location:
6; 6 D1
Exon count:
2
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (87428994..87434512)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (87378996..87384506)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene gastrokine 2 Neighboring gene gastrokine 3 Neighboring gene Rho GTPase activating protein 25 Neighboring gene prokineticin receptor 1 Neighboring gene predicted gene, 34222

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
hormone activity ISO
Inferred from Sequence Orthology
more info
 
receptor serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
telethonin binding ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 
SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
adult heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
atrial cardiac muscle tissue morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart trabecula formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle hypertrophy IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cardiac muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation involved in heart morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of pathway-restricted SMAD protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
regulation of cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
 
sarcomere organization ISO
Inferred from Sequence Orthology
more info
 
ventricular cardiac muscle cell development IDA
Inferred from Direct Assay
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Z disc ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bone morphogenetic protein 10
Names
BMP-10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009756.3NP_033886.2  bone morphogenetic protein 10 preproprotein

    See identical proteins and their annotated locations for NP_033886.2

    Status: REVIEWED

    Source sequence(s)
    AC155726, BC145983
    Consensus CDS
    CCDS51838.1
    UniProtKB/Swiss-Prot
    Q9R229
    Related
    ENSMUSP00000032125.5, ENSMUST00000032125.6
    Conserved Domains (2) summary
    pfam00019
    Location:318420
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:55256
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p6 C57BL/6J

    Range
    87428994..87434512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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