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OR56A1 olfactory receptor family 56 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 120796, updated on 2-Nov-2024

Summary

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Official Symbol
OR56A1provided by HGNC
Official Full Name
olfactory receptor family 56 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:14781
See related
Ensembl:ENSG00000180934 AllianceGenome:HGNC:14781
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-75
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR56A1 in Genome Data Viewer
Location:
11p15.4
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6019336..6034338, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6077838..6092837, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6040566..6055568, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 56 subfamily A member 3 Neighboring gene olfactory receptor family 56 subfamily A member 4 Neighboring gene RNA, 5S ribosomal pseudogene 329 Neighboring gene uncharacterized LOC107984303 Neighboring gene olfactory receptor family 56 subfamily A member 7 pseudogene Neighboring gene olfactory receptor family 52 subfamily L member 2 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 56A1
Names
olfactory receptor OR11-75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001917.5 → NP_001001917.3  olfactory receptor 56A1

    Status: VALIDATED

    Source sequence(s)
    AC111177
    Consensus CDS
    CCDS31405.2
    UniProtKB/Swiss-Prot
    B2RNI2, Q6IFL0, Q8NGH5
    UniProtKB/TrEMBL
    A0A126GVB5, A0A286YFC4
    Related
    ENSP00000493266.1, ENST00000641423.1
    Conserved Domains (2) summary
    cd14964
    Location:29 → 55
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:28 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. NM_001388488.1 → NP_001375417.1  olfactory receptor 56A1

    Status: VALIDATED

    Source sequence(s)
    AC111177
    Consensus CDS
    CCDS31405.2
    UniProtKB/Swiss-Prot
    B2RNI2, Q6IFL0, Q8NGH5
    UniProtKB/TrEMBL
    A0A126GVB5, A0A286YFC4
    Related
    ENSP00000493047.1, ENST00000641900.1
    Conserved Domains (2) summary
    cd14964
    Location:29 → 55
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:28 → 306
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    6019336..6034338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    6077838..6092837 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGH5.3 GenPept UniProtKB/Swiss-Prot:Q8NGH5

Gene LinkOut

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