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tph2 tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) [ Polypterus senegalus (gray bichir) ]

Gene ID: 120534373, updated on 8-May-2024

Summary

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Gene symbol
tph2
Gene description
tryptophan hydroxylase 2 (tryptophan 5-monooxygenase)
Locus tag
GTO96_0021781
See related
EnsemblRapid:ENSSTSG00000012452
Gene type
protein coding
RefSeq status
MODEL
Organism
Polypterus senegalus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Polypteriformes; Polypteridae; Polypterus
Orthologs
zebrafish all
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Genomic context

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See tph2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
12
Annotation release Status Assembly Chr Location
100 current ASM1683550v1 (GCF_016835505.1) 8 NC_053161.1 (149600256..149777666, complement)

Chromosome 8 - NC_053161.1Genomic Context describing neighboring genes Neighboring gene thyrotropin-releasing hormone-degrading ectoenzyme-like Neighboring gene uncharacterized LOC120534372 Neighboring gene uncharacterized LOC120533657 Neighboring gene TBC1 domain family, member 15 Neighboring gene RAB21, member RAS oncogene family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_053161.1 Chromosome 8 Reference ASM1683550v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tryptophan 5-hydroxylase 2
Names
TPH2 hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Polypterus senegalus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM1683550v1 Primary Assembly

Genomic

  1. NC_053161.1 Reference ASM1683550v1 Primary Assembly

    Range
    149600256..149777666 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039761916.1 → XP_039617850.1  tryptophan 5-hydroxylase 2 isoform X1

    UniProtKB/TrEMBL
    A0A8X8BME6
    Related
    ENSSTSP00000027637.1, ENSSTST00000031488.1
    Conserved Domains (2) summary
    cd04929
    Location:63 → 136
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:151 → 481
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

  2. XM_039761917.1 → XP_039617851.1  tryptophan 5-hydroxylase 2 isoform X2

    Conserved Domains (1) summary
    TIGR01270
    Location:55 → 355
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
Nucleotide Protein
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