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Bcl2l1 BCL2-like 1 [ Mus musculus (house mouse) ]

Gene ID: 12048, updated on 22-Jan-2023

Summary

Official Symbol
Bcl2l1provided by MGI
Official Full Name
BCL2-like 1provided by MGI
Primary source
MGI:MGI:88139
See related
Ensembl:ENSMUSG00000007659 AllianceGenome:MGI:88139
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BclX; Bcl2l; bcl-x; Bcl-XL; Bcl(X)L; bcl2-L-1
Summary
This gene encodes a member of the Bcl-2 family of apoptosis regulators. The encoded protein is localized to the inner and outer mitochondrial membranes and regulates the programmed cell death pathway during development and tissue homeostasis. This protein binds to voltage-dependent anion channels in the outer mitochondrial membrane to facilitate the uptake of calcium ions. Mice embryos lacking this gene survived for two weeks and exhibited cell death of immature hematopoietic cells and neurons. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jan 2014]
Expression
Ubiquitous expression in thymus adult (RPKM 18.5), liver E14.5 (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Bcl2l1 in Genome Data Viewer
Location:
2 75.41 cM; 2 H1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (152600652..152675723, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (152758732..152833803, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene high mobility group box 1-like pseudogene Neighboring gene predicted gene, 32057 Neighboring gene cytochrome c oxidase subunit 4I2 Neighboring gene predicted gene, 32211 Neighboring gene TPX2, microtubule-associated Neighboring gene microRNA 5622 Neighboring gene myosin, light polypeptide kinase 2, skeletal muscle

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC99998, MGC113803

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables clathrin binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process in bone marrow cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to alkaloid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to amino acid stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of dendritic cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within germ cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hepatocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mitochondrion morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of developmental process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of reproductive process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mononuclear cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synaptic vesicle clustering ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of synaptic vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane permeability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitochondrial membrane potential ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to cycloheximide IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cytokine ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to virus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within suppression by virus of host apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in synaptic vesicle recycling via endosome ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of PUMA-BCL-xl complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with clathrin-coated pit ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial envelope ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in presynapse ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
bcl-2-like protein 1
Names
B-cell leukemia/lymphoma x
anti-apoptosis regulatory protein
apoptosis regulator Bcl-X

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289716.1NP_001276645.1  bcl-2-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276645.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
    Source sequence(s)
    AK146461, AL731857, BB735910, BY286706
    Consensus CDS
    CCDS16899.1
    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Related
    ENSMUSP00000105445.4, ENSMUST00000109820.5
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator
  2. NM_001289717.1NP_001276646.1  bcl-2-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276646.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS16899.1
    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator
  3. NM_001289739.1NP_001276668.1  bcl-2-like protein 1 isoform b

    See identical proteins and their annotated locations for NP_001276668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has a different 3' structure resulting in a frameshift compared to variant 5. The resulting isoform (b, also known as Bcl-x gamma; PMID 9390687) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AK146461, AL731857, BY286706, U51277
    UniProtKB/TrEMBL
    O35843, Q5HZH3
    Conserved Domains (3) summary
    smart00265
    Location:127
    BH4; BH4 Bcl-2 homology region 4
    cd06845
    Location:81188
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:1188
    bcl-2; apoptosis regulator
  4. NM_001355053.1NP_001341982.1  bcl-2-like protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the shorter isoform (a, also known as Bcl-xL; PMID 7607090). Variants 1, 2, 3, and 5 all encode the same isoform (a).
    Source sequence(s)
    AL731857
    Consensus CDS
    CCDS16899.1
    UniProtKB/Swiss-Prot
    Q61338
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator
  5. NM_009743.5NP_033873.3  bcl-2-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_033873.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 1, 2, 3, and 5 all encode the same isoform (a, also known as Bcl-xL; PMID 7607090).
    Source sequence(s)
    AL731857, BB735910, BB856100, BC089016
    Consensus CDS
    CCDS16899.1
    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Related
    ENSMUSP00000007803.6, ENSMUST00000007803.12
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator

RNA

  1. NR_149254.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' end compared to variant 5. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 5.
    Source sequence(s)
    AL731857

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    152600652..152675723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498612.3XP_006498675.1  bcl-2-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006498675.1

    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator
  2. XM_011239260.3XP_011237562.1  bcl-2-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011237562.1

    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator
  3. XM_006498611.5XP_006498674.1  bcl-2-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006498674.1

    UniProtKB/Swiss-Prot
    Q61338, Q64373
    UniProtKB/TrEMBL
    A0A6P5P935, Q5HZH3
    Conserved Domains (1) summary
    TIGR00865
    Location:1233
    bcl-2; apoptosis regulator

RNA

  1. XR_374396.4 RNA Sequence