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Bcl2 B cell leukemia/lymphoma 2 [ Mus musculus (house mouse) ]

Gene ID: 12043, updated on 5-Jan-2023

Summary

Official Symbol
Bcl2provided by MGI
Official Full Name
B cell leukemia/lymphoma 2provided by MGI
Primary source
MGI:MGI:88138
See related
Ensembl:ENSMUSG00000057329 AllianceGenome:MGI:88138
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bcl-2; C430015F12Rik; D630044D05Rik; D830018M01Rik
Summary
This gene encodes a member of the B cell lymphoma 2 protein family. Members of this family regulate cell death in multiple cell types and can have either proapoptotic or antiapoptotic activities. The protein encoded by this gene inhibits mitochondrial-mediated apoptosis. This protein is an integral outer mitochondrial membrane protein that functions as part of signaling pathway that controls mitochondrial permeability in response to apoptotic stimuli. This protein may also play a role in neuron cell survival and autophagy. Abnormal expression and chromosomal translocations of this gene are associated with cancer progression in numerous tissues. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in spleen adult (RPKM 4.5), limb E14.5 (RPKM 2.8) and 23 other tissues See more
Orthologs
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Genomic context

See Bcl2 in Genome Data Viewer
Location:
1 E2.1; 1 49.76 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (106465906..106642020, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (106538176..106714290, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6651 Neighboring gene predicted gene, 41928 Neighboring gene microRNA 3473f Neighboring gene predicted gene, 37053 Neighboring gene 3-ketodihydrosphingosine reductase Neighboring gene vacuolar protein sorting 4B Neighboring gene predicted gene, 53577

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables BH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables channel activity ISO
Inferred from Sequence Orthology
more info
 
enables channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein phosphatase 2A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within B cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within CD8-positive, alpha-beta T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell lineage commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic mitochondrial changes IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within axon regeneration IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of calcium ion transport into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cochlear nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within developmental pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ear development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of establishment of localization in cell IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphoid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within melanin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within melanocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of motor neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of calcium ion transport into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cellular pH reduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of motor neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ovarian follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pigment granule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of developmental pigmentation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of melanocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within reactive oxygen species metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of catalytic activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of glycoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitochondrial membrane permeability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of nitrogen utilization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within renal system process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to UV-B IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to amino acid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to cytokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to cytokine ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to glucocorticoid IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to iron ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to ischemia ISO
Inferred from Sequence Orthology
more info
 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to steroid hormone IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to toxic substance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to toxic substance ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of smooth muscle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ureteric bud development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of BAD-BCL-2 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in mitochondrial crista ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of pore complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009741.5NP_033871.2  apoptosis regulator Bcl-2 isoform 1

    See identical proteins and their annotated locations for NP_033871.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC122842, AC162916, BC095964
    Consensus CDS
    CCDS15209.1
    UniProtKB/Swiss-Prot
    P10417, Q4VBF6
    Related
    ENSMUSP00000108371.2, ENSMUST00000112751.2
    Conserved Domains (3) summary
    smart00265
    Location:733
    BH4; BH4 Bcl-2 homology region 4
    cd06845
    Location:81198
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:11236
    bcl-2; apoptosis regulator
  2. NM_177410.3NP_803129.2  apoptosis regulator Bcl-2 isoform 2

    See identical proteins and their annotated locations for NP_803129.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC122842, AK049473, BC068988, BY118935
    Consensus CDS
    CCDS78667.1
    UniProtKB/TrEMBL
    Q6NTH7, Q8BQK4
    Related
    ENSMUSP00000139856.2, ENSMUST00000189999.2
    Conserved Domains (3) summary
    smart00265
    Location:733
    BH4; BH4 Bcl-2 homology region 4
    cd06845
    Location:81196
    Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    TIGR00865
    Location:11196
    bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    106465906..106642020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)