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Bcat1 branched chain aminotransferase 1, cytosolic [ Mus musculus (house mouse) ]

Gene ID: 12035, updated on 30-Oct-2022

Summary

Official Symbol
Bcat1provided by MGI
Official Full Name
branched chain aminotransferase 1, cytosolicprovided by MGI
Primary source
MGI:MGI:104861
See related
Ensembl:ENSMUSG00000030268 AllianceGenome:MGI:104861
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCATc; Eca39
Summary
Enables branched-chain-amino-acid transaminase activity. Acts upstream of or within branched-chain amino acid catabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; craniocervical region bone; limb; nervous system; and sensory organ. Orthologous to human BCAT1 (branched chain amino acid transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 2.3), ovary adult (RPKM 2.1) and 12 other tissues See more
Orthologs
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Genomic context

See Bcat1 in Genome Data Viewer
Location:
6 G3; 6 77.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (144939561..145021883, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (144993835..145076157, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32124 Neighboring gene predicted gene, 20124 Neighboring gene predicted gene, 53314 Neighboring gene predicted gene, 46721 Neighboring gene predicted gene, 26666 Neighboring gene predicted gene, 38925 Neighboring gene inositol 1,4,5-triphosphate receptor associated 2 Neighboring gene predicted gene 15543 Neighboring gene dynein axonemal intermediate chain 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-isoleucine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-leucine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-valine transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables branched-chain-amino-acid transaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables branched-chain-amino-acid transaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables branched-chain-amino-acid transaminase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
branched-chain-amino-acid aminotransferase, cytosolic
Names
BCAT(c)
NP_001019639.1
NP_031558.3
XP_011239868.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024468.3NP_001019639.1  branched-chain-amino-acid aminotransferase, cytosolic isoform 1

    See identical proteins and their annotated locations for NP_001019639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC140416, AK036309, AW491045
    Consensus CDS
    CCDS20691.1
    UniProtKB/TrEMBL
    Q8CBC8
    Related
    ENSMUSP00000032402.6, ENSMUST00000032402.12
    Conserved Domains (2) summary
    PRK13357
    Location:100453
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:148442
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...
  2. NM_007532.5NP_031558.3  branched-chain-amino-acid aminotransferase, cytosolic isoform 2

    See identical proteins and their annotated locations for NP_031558.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and unique N-terminus, compared to isoform 1.
    Source sequence(s)
    AC140416, AK167232, AW491045, BY781109
    Consensus CDS
    CCDS39703.1
    UniProtKB/Swiss-Prot
    P24288, Q7TMT2
    UniProtKB/TrEMBL
    Q3TJN1
    Related
    ENSMUSP00000107371.2, ENSMUST00000111742.8
    Conserved Domains (2) summary
    PRK13357
    Location:33386
    PRK13357; branched-chain amino acid aminotransferase; Provisional
    cd01557
    Location:81375
    BCAT_beta_family; BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    144939561..145021883 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241566.3XP_011239868.1  branched-chain-amino-acid aminotransferase, cytosolic isoform X1

    Conserved Domains (1) summary
    PRK13357
    Location:32385
    PRK13357; branched-chain amino acid aminotransferase; Provisional