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Akr1b7 aldo-keto reductase family 1, member B7 [ Mus musculus (house mouse) ]

Gene ID: 11997, updated on 7-May-2024

Summary

Official Symbol
Akr1b7provided by MGI
Official Full Name
aldo-keto reductase family 1, member B7provided by MGI
Primary source
MGI:MGI:101918
See related
Ensembl:ENSMUSG00000052131 AllianceGenome:MGI:101918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AR; Avdp; MVDP
Summary
Predicted to enable several functions, including alcohol dehydrogenase (NADP+) activity; geranylgeranyl reductase activity; and indanol dehydrogenase activity. Predicted to be involved in several processes, including cellular detoxification of aldehyde; daunorubicin metabolic process; and primary alcohol metabolic process. Predicted to act upstream of or within cellular lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland and genitourinary system. Orthologous to human AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 247.9), adrenal adult (RPKM 164.8) and 1 other tissue See more
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Genomic context

See Akr1b7 in Genome Data Viewer
Location:
6 B1; 6 14.95 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34389297..34400072)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34412362..34423137)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene cancer susceptibility candidate 4 pseudogene Neighboring gene RIO kinase 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:34334195-34334304 Neighboring gene aldo-keto reductase family 1, member B10 Neighboring gene aldo-keto reductase family 1, member B7 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr6:34426033-34426334 Neighboring gene 2,3-bisphosphoglycerate mutase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC107658

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alcohol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables all-trans-retinol dehydrogenase (NADP+) activity ISO
Inferred from Sequence Orthology
more info
 
enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
enables geranylgeranyl reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables indanol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
enables retinal dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aldo-keto reductase family 1 member B7
Names
aldehyde reductase
aldose reductase-related protein 1
androgen regulated vas deferens protein
vas deferens androgen-dependent protein
NP_033861.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009731.2NP_033861.2  aldo-keto reductase family 1 member B7

    See identical proteins and their annotated locations for NP_033861.2

    Status: VALIDATED

    Source sequence(s)
    BC086929, CN833345
    Consensus CDS
    CCDS19993.1
    UniProtKB/Swiss-Prot
    P21300
    UniProtKB/TrEMBL
    Q3UGS8, Q5M9J9
    Related
    ENSMUSP00000007449.8, ENSMUST00000007449.9
    Conserved Domains (1) summary
    cd19107
    Location:10316
    AKR_AKR1B1-19; AKR1B family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34389297..34400072
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)