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Auh AU RNA binding protein/enoyl-coenzyme A hydratase [ Mus musculus (house mouse) ]

Gene ID: 11992, updated on 1-Mar-2024

Summary

Official Symbol
Auhprovided by MGI
Official Full Name
AU RNA binding protein/enoyl-coenzyme A hydrataseprovided by MGI
Primary source
MGI:MGI:1338011
See related
Ensembl:ENSMUSG00000021460 AllianceGenome:MGI:1338011
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables RNA binding activity and enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to act upstream of or within branched-chain amino acid catabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 1 and renal tubular transport disease. Orthologous to human AUH (AU RNA binding methylglutaconyl-CoA hydratase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 10.0), kidney adult (RPKM 9.4) and 28 other tissues See more
Orthologs
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Genomic context

See Auh in Genome Data Viewer
Location:
13 A5- B1; 13 27.68 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (52989155..53083742, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (52835107..52929704, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:52678844-52678953 Neighboring gene STARR-seq mESC enhancer starr_34550 Neighboring gene STARR-positive B cell enhancer ABC_E7238 Neighboring gene spleen tyrosine kinase Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:52797592-52797775 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:52816883-52817066 Neighboring gene expressed sequence BB123696 Neighboring gene STARR-seq mESC enhancer starr_34551 Neighboring gene predicted gene, 33315 Neighboring gene STARR-seq mESC enhancer starr_34553 Neighboring gene STARR-positive B cell enhancer ABC_E3081 Neighboring gene STARR-positive B cell enhancer mm9_chr13:53024873-53025174 Neighboring gene STARR-seq mESC enhancer starr_34554 Neighboring gene STARR-positive B cell enhancer ABC_E4070 Neighboring gene predicted gene, 40950 Neighboring gene nuclear factor, interleukin 3, regulated

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables enoyl-CoA hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enoyl-CoA hydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables enoyl-CoA hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables itaconyl-CoA hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
 
enables methylglutaconyl-CoA hydratase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
methylglutaconyl-CoA hydratase, mitochondrial
Names
3-MG-CoA hydratase
AU-binding enoyl-CoA hydratase
AU-specific RNA-binding enoyl-CoA hydratase
itaconyl-CoA hydratase
muAUH
NP_001413039.1
NP_001413040.1
NP_001413041.1
NP_001413042.1
NP_001413043.1
NP_001413044.1
NP_001413045.1
NP_001413046.1
NP_001413047.1
NP_001413048.1
NP_001413049.1
NP_001413050.1
NP_001413051.1
NP_057918.2
XP_006516909.1
XP_017170862.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426110.1NP_001413039.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  2. NM_001426111.1NP_001413040.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  3. NM_001426112.1NP_001413041.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  4. NM_001426113.1NP_001413042.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  5. NM_001426114.1NP_001413043.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  6. NM_001426115.1NP_001413044.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  7. NM_001426116.1NP_001413045.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  8. NM_001426117.1NP_001413046.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  9. NM_001426118.1NP_001413047.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
  10. NM_001426119.1NP_001413048.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
  11. NM_001426120.1NP_001413049.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
  12. NM_001426121.1NP_001413050.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
  13. NM_001426122.1NP_001413051.1  methylglutaconyl-CoA hydratase, mitochondrial isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
  14. NM_016709.3NP_057918.2  methylglutaconyl-CoA hydratase, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_057918.2

    Status: VALIDATED

    Source sequence(s)
    AC140443, AC160765
    Consensus CDS
    CCDS26518.1
    UniProtKB/Swiss-Prot
    Q80YD7, Q8QZS0, Q9CY78, Q9D155, Q9JLZ3
    UniProtKB/TrEMBL
    A0A0R4J023
    Related
    ENSMUSP00000021913.10, ENSMUST00000021913.16
    Conserved Domains (1) summary
    cl23717
    Location:61314
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    52989155..53083742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315373.3XP_017170862.1  methylglutaconyl-CoA hydratase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    E9QMT1
    Conserved Domains (1) summary
    cl23717
    Location:61114
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  2. XM_006516846.5XP_006516909.1  methylglutaconyl-CoA hydratase, mitochondrial isoform X2

    UniProtKB/TrEMBL
    E9QMT1
    Related
    ENSMUSP00000105658.4, ENSMUST00000110031.4
    Conserved Domains (1) summary
    cl23717
    Location:61114
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RNA

  1. XR_003950422.2 RNA Sequence