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Atp6v0d1 ATPase, H+ transporting, lysosomal V0 subunit D1 [ Mus musculus (house mouse) ]

Gene ID: 11972, updated on 12-May-2024

Summary

Official Symbol
Atp6v0d1provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit D1provided by MGI
Primary source
MGI:MGI:1201778
See related
Ensembl:ENSMUSG00000013160 AllianceGenome:MGI:1201778
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P39; Ac39; VATX; Vma6; Atp6d
Summary
Contributes to proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular cation homeostasis; cellular response to increased oxygen levels; and vacuolar transport. Predicted to act upstream of or within cell projection organization and ion transport. Located in early endosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Orthologous to human ATP6V0D1 (ATPase H+ transporting V0 subunit d1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 82.2), cerebellum adult (RPKM 80.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atp6v0d1 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106251093..106292696, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105524461..105566064, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 pseudogene Neighboring gene hydroxysteroid 11-beta dehydrogenase 2 Neighboring gene STARR-positive B cell enhancer ABC_E10519 Neighboring gene STARR-positive B cell enhancer ABC_E11395 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108090885-108090994 Neighboring gene predicted gene, 38250 Neighboring gene agouti related neuropeptide Neighboring gene predicted gene 45855

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Gene trapped (1) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to increased oxygen levels ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular iron ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle lumen acidification EXP
Inferred from Experiment
more info
PubMed 
involved_in synaptic vesicle lumen acidification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle lumen acidification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in vacuolar transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
part_of plasma membrane proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of proton-transporting V-type ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proton-transporting V-type ATPase, V0 domain IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of transmembrane transporter complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of vacuolar proton-transporting V-type ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of vacuolar proton-transporting V-type ATPase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
V-type proton ATPase subunit d 1
Names
ATPase, H+ transporting, V0 subunit D
ATPase, H+ transporting, lysosomal (vacuolar proton pump), 42 kDa
ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D
V-ATPase 40 kDa accessory protein
V-ATPase AC39 subunit
V-ATPase subunit d 1
lysosomal 38kDa
physophilin
vacuolar proton pump subunit d 1
NP_038505.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013477.4NP_038505.2  V-type proton ATPase subunit d 1

    See identical proteins and their annotated locations for NP_038505.2

    Status: VALIDATED

    Source sequence(s)
    AC151573, AK083372, CD776853
    Consensus CDS
    CCDS22604.1
    UniProtKB/Swiss-Prot
    P51863, Q54A57, Q9QWJ2
    UniProtKB/TrEMBL
    Q921S5
    Related
    ENSMUSP00000013304.7, ENSMUST00000013304.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106251093..106292696 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)