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CLK2 CDC like kinase 2 [ Homo sapiens (human) ]

Gene ID: 1196, updated on 7-Jun-2020

Summary

Official Symbol
CLK2provided by HGNC
Official Full Name
CDC like kinase 2provided by HGNC
Primary source
HGNC:HGNC:2069
See related
Ensembl:ENSG00000176444 MIM:602989
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. Chromosomal translocations have been characterized between this locus and the PAFAH1B3 (platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)) gene on chromosome 19, resulting in the production of a fusion protein. Note that this gene is distinct from the TELO2 gene (GeneID:9894), which shares the CLK2 alias, but encodes a protein that is involved in telomere length regulation. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Expression
Ubiquitous expression in spleen (RPKM 18.0), lymph node (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See CLK2 in Genome Data Viewer
Location:
1q22
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155262868..155273504, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155232659..155243305, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 189 member B Neighboring gene secretory carrier membrane protein 3 Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 3 Neighboring gene pyruvate kinase L/R Neighboring gene farnesyl diphosphate synthase Neighboring gene RUSC1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61500

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of gluconeogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of RNA splicing IDA
Inferred from Direct Assay
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
dual specificity protein kinase CLK2
Names
CLK kinase
NP_001281267.1
NP_001281268.1
NP_001350633.1
NP_003984.2
XP_011507445.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294338.2NP_001281267.1  dual specificity protein kinase CLK2 isoform 1

    See identical proteins and their annotated locations for NP_001281267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL713999, BC014067, BC053603, HY049688
    Consensus CDS
    CCDS72939.1
    UniProtKB/Swiss-Prot
    P49760
    UniProtKB/TrEMBL
    A8K7I0
    Related
    ENSP00000357345.4, ENST00000368361.9
    Conserved Domains (1) summary
    cd14215
    Location:150479
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2
  2. NM_001294339.2NP_001281268.1  dual specificity protein kinase CLK2 isoform 3

    See identical proteins and their annotated locations for NP_001281268.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AU136826, BC014067, HY049688, L29216
    UniProtKB/Swiss-Prot
    P49760
    UniProtKB/TrEMBL
    B7Z8N6
    Related
    ENST00000476983.5
    Conserved Domains (1) summary
    cl21453
    Location:1251
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001363704.2NP_001350633.1  dual specificity protein kinase CLK2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses multiple alternate in-frame splice sites, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL713999
    Consensus CDS
    CCDS86020.1
    Related
    ENSP00000347759.4, ENST00000355560.4
    Conserved Domains (1) summary
    cd14215
    Location:148477
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2
  4. NM_003993.4NP_003984.2  dual specificity protein kinase CLK2 isoform 2

    See identical proteins and their annotated locations for NP_003984.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AU136826, BC014067, HY049688
    Consensus CDS
    CCDS1107.1
    UniProtKB/Swiss-Prot
    P49760
    Related
    ENSP00000354856.5, ENST00000361168.9
    Conserved Domains (1) summary
    cd14215
    Location:149478
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155262868..155273504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509143.2XP_011507445.1  dual specificity protein kinase CLK2 isoform X1

    See identical proteins and their annotated locations for XP_011507445.1

    Conserved Domains (1) summary
    cd14215
    Location:149478
    PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315906.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    67891..78527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001291.2: Suppressed sequence

    Description
    NM_001291.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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