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GSTO2 glutathione S-transferase omega 2 [ Homo sapiens (human) ]

Gene ID: 119391, updated on 2-Mar-2021

Summary

Official Symbol
GSTO2provided by HGNC
Official Full Name
glutathione S-transferase omega 2provided by HGNC
Primary source
HGNC:HGNC:23064
See related
Ensembl:ENSG00000065621 MIM:612314
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSTO 2-2; bA127L20.1
Summary
The protein encoded by this gene is an omega class glutathione S-transferase (GST). GSTs are involved in the metabolism of xenobiotics and carcinogens. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2010]
Expression
Broad expression in skin (RPKM 2.1), testis (RPKM 1.8) and 21 other tissues See more
Orthologs
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Genomic context

See GSTO2 in Genome Data Viewer
Location:
10q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (104267626..104304950)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106028942..106064708)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene microRNA 609 Neighboring gene glutathione S-transferase omega 1 Neighboring gene microRNA 4482 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene ITPRIP antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11867

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione dehydrogenase (ascorbate) activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
methylarsonate reductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-ascorbic acid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
L-ascorbic acid metabolic process TAS
Traceable Author Statement
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase omega-2
Names
GSTO-2
MMA(V) reductase
bA127L20.1 (novel glutathione-S-transferase)
glutathione S-transferase omega 2-2
glutathione-S-transferase-like protein
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_001177942.1
NP_001177943.1
NP_001177944.1
NP_899062.1
XP_006717687.1
XP_011537572.1
XP_011537573.1
XP_011537574.1
XP_011537575.1
XP_016871159.1
XP_016871160.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023363.1 RefSeqGene

    Range
    5001..35546
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191013.2NP_001177942.1  glutathione S-transferase omega-2 isoform 2

    See identical proteins and their annotated locations for NP_001177942.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AL162742, BC056918, DC341647
    Consensus CDS
    CCDS53574.1
    UniProtKB/Swiss-Prot
    Q9H4Y5
    Related
    ENSP00000390986.2, ENST00000450629.6
    Conserved Domains (3) summary
    COG0625
    Location:26177
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:108196
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  2. NM_001191014.2NP_001177943.1  glutathione S-transferase omega-2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to isoform 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL162742, BC046194, BC056918
    Consensus CDS
    CCDS53575.1
    UniProtKB/Swiss-Prot
    Q9H4Y5
    Related
    ENSP00000358721.1, ENST00000369707.2
    Conserved Domains (3) summary
    cd03184
    Location:80202
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:4183
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:166
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_001191015.2NP_001177944.1  glutathione S-transferase omega-2 isoform 4

    See identical proteins and their annotated locations for NP_001177944.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence, and lacks an alternate in-frame exon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AL162742, BC046194, BC056918, BM708208
    UniProtKB/Swiss-Prot
    Q9H4Y5
    Conserved Domains (3) summary
    COG0625
    Location:4149
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:166
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:80168
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  4. NM_183239.2NP_899062.1  glutathione S-transferase omega-2 isoform 1

    See identical proteins and their annotated locations for NP_899062.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL162742, BC056918
    Consensus CDS
    CCDS7556.1
    UniProtKB/Swiss-Prot
    Q9H4Y5
    Related
    ENSP00000345023.1, ENST00000338595.7
    Conserved Domains (2) summary
    cd03184
    Location:108230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    104267626..104304950
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539270.3XP_011537572.1  glutathione S-transferase omega-2 isoform X1

    See identical proteins and their annotated locations for XP_011537572.1

    UniProtKB/Swiss-Prot
    Q9H4Y5
    Conserved Domains (2) summary
    cd03184
    Location:108230
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_011539273.2XP_011537575.1  glutathione S-transferase omega-2 isoform X4

    Conserved Domains (3) summary
    COG0625
    Location:26142
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:108122
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  3. XM_006717624.3XP_006717687.1  glutathione S-transferase omega-2 isoform X2

    Conserved Domains (3) summary
    COG0625
    Location:26120
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:108157
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  4. XM_011539271.2XP_011537573.1  glutathione S-transferase omega-2 isoform X3

    See identical proteins and their annotated locations for XP_011537573.1

    Conserved Domains (3) summary
    COG0625
    Location:26120
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:108166
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
  5. XM_017015670.2XP_016871159.1  glutathione S-transferase omega-2 isoform X5

  6. XM_017015671.1XP_016871160.1  glutathione S-transferase omega-2 isoform X5

  7. XM_011539272.3XP_011537574.1  glutathione S-transferase omega-2 isoform X3

    See identical proteins and their annotated locations for XP_011537574.1

    Conserved Domains (3) summary
    COG0625
    Location:26120
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cl00388
    Location:794
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:108166
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family
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