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LOC119369031 CRISPRi-FlowFISH-validated BAX, FTL and NUCB1 regulatory element [ Homo sapiens (human) ]

Gene ID: 119369031, discontinued on 17-Nov-2022

Summary

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Gene symbol
LOC119369031
Gene description
CRISPRi-FlowFISH-validated BAX, FTL and NUCB1 regulatory element
Gene type
biological region
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic region was predicted to be an enhancer based on an activity-by-contact (ABC) model that predicts enhancer-gene connections, where the putative enhancer strength is measured by DNase I hypersensitivity and H3K27 acetylation, and the contact frequency by Hi-C. It was validated as a negatively-acting cis-regulatory element for each of the BAX (BCL2 associated X, apoptosis regulator), FTL (ferritin light chain) and NUCB1 (nucleobindin 1) genes based on CRISPR/Cas9-mediated perturbation (CRISPRi-FlowFISH method) in K562 erythroleukemia cells. [provided by RefSeq, Nov 2020]
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Genomic context

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Location:
19q
Annotation release Status Assembly Chr Location
110 latest, but not current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (48873488..48873988)
110 latest, but not current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (51868351..51868851)

Bibliography

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GeneRIFs: Gene References Into Functions