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LYZL2 lysozyme like 2 [ Homo sapiens (human) ]

Gene ID: 119180, updated on 17-Jun-2019

Summary

Official Symbol
LYZL2provided by HGNC
Official Full Name
lysozyme like 2provided by HGNC
Primary source
HGNC:HGNC:29613
See related
Ensembl:ENSG00000151033 MIM:612748
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYZD2
Summary
Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Expression
Restricted expression toward testis (RPKM 14.7) See more
Orthologs

Genomic context

See LYZL2 in Genome Data Viewer
Location:
10p11.23
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (30606222..30629761, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (30900708..30918647, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 63, pseudogene Neighboring gene uncharacterized LOC105376479 Neighboring gene supervillin family member 2, pseudogene Neighboring gene long intergenic non-protein coding RNA 2644

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lysozyme activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lysozyme-like protein 2
Names
lysozyme D2
lysozyme-2
NP_898881.3
XP_011517608.1
XP_011517609.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_183058.3NP_898881.3  lysozyme-like protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AF139543, AI637906, AL451107, BC066294
    Consensus CDS
    CCDS7167.2
    Related
    ENSP00000364467.2, ENST00000375318.4
    Conserved Domains (1) summary
    cd00119
    Location:20143
    LYZ1; C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    30606222..30629761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519306.2XP_011517608.1  lysozyme-like protein 2 isoform X1

    Conserved Domains (1) summary
    cl00222
    Location:66145
    lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...
  2. XM_011519307.2XP_011517609.1  lysozyme-like protein 2 isoform X2

    Conserved Domains (1) summary
    cl00222
    Location:66146
    lysozyme_like; lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases. ...

RNA

  1. XR_930469.2 RNA Sequence

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