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CLU clusterin [ Homo sapiens (human) ]

Gene ID: 1191, updated on 27-Nov-2024

Summary

Official Symbol
CLUprovided by HGNC
Official Full Name
clusterinprovided by HGNC
Primary source
HGNC:HGNC:2095
See related
Ensembl:ENSG00000120885 MIM:185430; AllianceGenome:HGNC:2095
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2
Summary
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
Expression
Broad expression in brain (RPKM 523.1), liver (RPKM 432.6) and 16 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See CLU in Genome Data Viewer
Location:
8p21.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (27596917..27614700, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (27874264..27892057, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (27454434..27472217, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19049 Neighboring gene epoxide hydrolase 2 Neighboring gene MPRA-validated peak6969 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27412252-27412752 Neighboring gene Sharpr-MPRA regulatory region 1589 Neighboring gene uncharacterized LOC124901919 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27450407-27450907 Neighboring gene gulonolactone (L-) oxidase, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27466546-27467252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27467959-27468666 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:27470630-27470815 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:27471849-27472348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27473305-27473805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27474096-27474852 Neighboring gene microRNA 6843 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27491053-27491882 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:27491883-27492711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:27508580-27509080 Neighboring gene scavenger receptor class A member 3 Neighboring gene RNA, U6 small nuclear 1086, pseudogene Neighboring gene uncharacterized LOC124901921

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
EBI GWAS Catalog
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
EBI GWAS Catalog
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
EBI GWAS Catalog
Genome-wide association study of panic disorder in the Japanese population.
EBI GWAS Catalog
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
EBI GWAS Catalog
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC24903

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
PubMed 
enables amyloid-beta binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables misfolded protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein carrier chaperone IDA
Inferred from Direct Assay
more info
PubMed 
enables protein heterodimerization activity TAS
Traceable Author Statement
more info
PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in central nervous system myelin maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaperone-mediated protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chaperone-mediated protein folding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement activation TAS
Traceable Author Statement
more info
PubMed 
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in immune complex clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid fibril formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid fibril formation TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid fibril formation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neurofibrillary tangle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein targeting to lysosome involved in chaperone-mediated autophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of amyloid-beta clearance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuronal signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in release of cytochrome c from mitochondria IC
Inferred by Curator
more info
PubMed 
involved_in response to misfolded protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in reverse cholesterol transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in blood microparticle HDA PubMed 
colocalizes_with cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromaffin granule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
colocalizes_with cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neurofibrillary tangle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex TAS
Traceable Author Statement
more info
PubMed 
part_of spherical high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
clusterin
Names
aging-associated protein 4
apolipoprotein J
complement cytolysis inhibitor
complement lysis inhibitor
complement-associated protein SP-40,40
epididymis secretory sperm binding protein
ku70-binding protein 1
sulfated glycoprotein 2
testosterone-repressed prostate message 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027845.1 RefSeqGene

    Range
    5111..22894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001831.4NP_001822.3  clusterin isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001822.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AF311103, BC010514, BM682289, DN990822
    Consensus CDS
    CCDS47832.1
    UniProtKB/Swiss-Prot
    B2R9Q1, B3KSE6, P10909, P11380, P11381, Q2TU75, Q5HYC1, Q7Z5B9
    UniProtKB/TrEMBL
    A0A384NKS6
    Related
    ENSP00000315130.10, ENST00000316403.15
    Conserved Domains (1) summary
    pfam01093
    Location:30445
    Clusterin

RNA

  1. NR_038335.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF311103
  2. NR_045494.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AF311103, BC019588, BM682289, BP193735, EB385800

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    27596917..27614700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    27874264..27892057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)