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Ass1 argininosuccinate synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 11898, updated on 5-Mar-2024

Summary

Official Symbol
Ass1provided by MGI
Official Full Name
argininosuccinate synthetase 1provided by MGI
Primary source
MGI:MGI:88090
See related
Ensembl:ENSMUSG00000076441 AllianceGenome:MGI:88090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASS; fold; Ass-1
Summary
Predicted to enable several functions, including argininosuccinate synthase activity; identical protein binding activity; and toxic substance binding activity. Involved in circadian rhythm. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; metanephros; and sensory organ. Used to study citrullinemia. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 1308.6), kidney adult (RPKM 838.7) and 2 other tissues See more
Orthologs
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Genomic context

See Ass1 in Genome Data Viewer
Location:
2 B; 2 21.81 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (31360282..31410682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (31470270..31520670)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:31112123-31112306 Neighboring gene neuronal calcium sensor 1 Neighboring gene STARR-seq mESC enhancer starr_04149 Neighboring gene hemicentin 2 Neighboring gene STARR-positive B cell enhancer ABC_E504 Neighboring gene predicted gene, 32952 Neighboring gene STARR-seq mESC enhancer starr_04154 Neighboring gene predicted gene 13426 Neighboring gene far upstream element (FUSE) binding protein 3 Neighboring gene microRNA 6998

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103151

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables argininosuccinate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables argininosuccinate synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in arginine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in arginine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in argininosuccinate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in argininosuccinate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in aspartate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
 
involved_in citrulline metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of leukocyte cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to glucocorticoid ISO
Inferred from Sequence Orthology
more info
 
involved_in response to mycotoxin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to zinc ion ISO
Inferred from Sequence Orthology
more info
 
involved_in urea cycle IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in urea cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
argininosuccinate synthase
Names
arginosuccinate synthetase 1
citrulline--aspartate ligase
NP_031520.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007494.3NP_031520.1  argininosuccinate synthase

    See identical proteins and their annotated locations for NP_031520.1

    Status: VALIDATED

    Source sequence(s)
    AL732564
    Consensus CDS
    CCDS15898.1
    UniProtKB/Swiss-Prot
    P16460
    UniProtKB/TrEMBL
    Q3UEJ7, Q3UJ34
    Related
    ENSMUSP00000099904.5, ENSMUST00000102840.5
    Conserved Domains (1) summary
    pfam00764
    Location:8401
    Arginosuc_synth; Arginosuccinate synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    31360282..31410682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)