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ZFYVE27 zinc finger FYVE-type containing 27 [ Homo sapiens (human) ]

Gene ID: 118813, updated on 4-Jul-2021

Summary

Official Symbol
ZFYVE27provided by HGNC
Official Full Name
zinc finger FYVE-type containing 27provided by HGNC
Primary source
HGNC:HGNC:26559
See related
Ensembl:ENSG00000155256 MIM:610243
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPG33; PROTRUDIN
Summary
This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in small intestine (RPKM 6.9), duodenum (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZFYVE27 in Genome Data Viewer
Location:
10q24.2
Exon count:
16
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (97737123..97760896)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99496885..99520652)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arginine vasopressin induced 1 Neighboring gene MARVEL domain containing 1 Neighboring gene Sharpr-MPRA regulatory region 10521 Neighboring gene secreted frizzled related protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum tubular network formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endoplasmic reticulum tubular network formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neurotrophin TRK receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neurotrophin TRK receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of axon extension IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of axon extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vesicle-mediated transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum tubular network IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum tubular network IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in growth cone membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in growth cone membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protrudin
Names
spastic paraplegia 33 protein
zinc finger FYVE domain containing 27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017075.1 RefSeqGene

    Range
    5008..28775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001002261.4NP_001002261.1  protrudin isoform 1

    See identical proteins and their annotated locations for NP_001002261.1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS31262.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Conserved Domains (1) summary
    cd15723
    Location:354414
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  2. NM_001002262.4NP_001002262.1  protrudin isoform 3

    See identical proteins and their annotated locations for NP_001002262.1

    Status: REVIEWED

    Source sequence(s)
    AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
    Consensus CDS
    CCDS31264.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000353069.3, ENST00000359980.5
    Conserved Domains (1) summary
    cd15723
    Location:342402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  3. NM_001174119.2NP_001167590.1  protrudin isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53562.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000337993.7, ENST00000337540.11
    Conserved Domains (1) summary
    cd15723
    Location:310370
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  4. NM_001174120.2NP_001167591.1  protrudin isoform 5

    See identical proteins and their annotated locations for NP_001167591.1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53563.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000350148.4, ENST00000357540.8
    Conserved Domains (1) summary
    cd15723
    Location:256316
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  5. NM_001174121.2NP_001167592.1  protrudin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53565.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000359642.3, ENST00000370610.7
    Conserved Domains (1) summary
    cd15723
    Location:249309
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  6. NM_001174122.2NP_001167593.1  protrudin isoform 7

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Consensus CDS
    CCDS53564.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000359646.3, ENST00000370613.7
    Conserved Domains (1) summary
    cd15723
    Location:224284
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  7. NM_001385871.1NP_001372800.1  protrudin isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Related
    ENSP00000409594.2, ENST00000423811.3
    Conserved Domains (1) summary
    cd15723
    Location:354414
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  8. NM_001385875.1NP_001372804.1  protrudin isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Related
    ENSP00000506975.1, ENST00000684270.1
    Conserved Domains (1) summary
    cd15723
    Location:349409
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  9. NM_001385876.1NP_001372805.1  protrudin isoform 8

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:360420
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  10. NM_001385877.1NP_001372806.1  protrudin isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:348408
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  11. NM_001385878.1NP_001372807.1  protrudin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347407
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  12. NM_001385879.1NP_001372808.1  protrudin isoform 10

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347407
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  13. NM_001385880.1NP_001372809.1  protrudin isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  14. NM_001385881.1NP_001372810.1  protrudin isoform 15

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342402
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  15. NM_001385882.1NP_001372811.1  protrudin isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:347389
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  16. NM_001385883.1NP_001372812.1  protrudin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342384
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  17. NM_001385884.1NP_001372813.1  protrudin isoform 12

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:342384
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  18. NM_001385885.1NP_001372814.1  protrudin isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:322382
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  19. NM_001385886.1NP_001372815.1  protrudin isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  20. NM_001385887.1NP_001372816.1  protrudin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  21. NM_001385888.1NP_001372817.1  protrudin isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:315375
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  22. NM_001385889.1NP_001372818.1  protrudin isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:310370
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  23. NM_001385890.1NP_001372819.1  protrudin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:286346
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  24. NM_001385891.1NP_001372820.1  protrudin isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:286346
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  25. NM_001385892.1NP_001372821.1  protrudin isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:281341
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  26. NM_001385893.1NP_001372822.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  27. NM_001385894.1NP_001372823.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  28. NM_001385895.1NP_001372824.1  protrudin isoform 20

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:279339
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  29. NM_001385896.1NP_001372825.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:274334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  30. NM_001385897.1NP_001372826.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:274334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  31. NM_001385898.1NP_001372827.1  protrudin isoform 21

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:274334
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  32. NM_001385899.1NP_001372828.1  protrudin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:270330
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  33. NM_001385900.1NP_001372829.1  protrudin isoform 22

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:270330
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  34. NM_001385901.1NP_001372830.1  protrudin isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  35. NM_001385902.1NP_001372831.1  protrudin isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  36. NM_001385903.1NP_001372832.1  protrudin isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  37. NM_001385904.1NP_001372833.1  protrudin isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:268328
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  38. NM_001385905.1NP_001372834.1  protrudin isoform 25

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  39. NM_001385906.1NP_001372835.1  protrudin isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  40. NM_001385908.1NP_001372837.1  protrudin isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:263323
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  41. NM_001385911.1NP_001372840.1  protrudin isoform 27

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:261321
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  42. NM_001385915.1NP_001372844.1  protrudin isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:249309
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  43. NM_001385916.1NP_001372845.1  protrudin isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:231291
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  44. NM_001385918.1NP_001372847.1  protrudin isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:231291
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  45. NM_001385919.1NP_001372848.1  protrudin isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL358938
    Conserved Domains (1) summary
    cd15723
    Location:131191
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  46. NM_144588.7NP_653189.3  protrudin isoform 2

    See identical proteins and their annotated locations for NP_653189.3

    Status: REVIEWED

    Source sequence(s)
    AK074876, AL358938, AL561314, BC030621, BF063694, DC302372
    Consensus CDS
    CCDS31263.1
    UniProtKB/Swiss-Prot
    Q5T4F4
    Related
    ENSP00000377282.3, ENST00000393677.8
    Conserved Domains (1) summary
    cd15723
    Location:349409
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins

RNA

  1. NR_169794.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  2. NR_169795.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  3. NR_169796.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  4. NR_169797.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  5. NR_169798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  6. NR_169799.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  7. NR_169800.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  8. NR_169801.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  9. NR_169802.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  10. NR_169803.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  11. NR_169804.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  12. NR_169805.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  13. NR_169806.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  14. NR_169808.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  15. NR_169809.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  16. NR_169810.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938
  17. NR_169811.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358938

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    97737123..97760896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269508.4XP_005269565.1  protrudin isoform X15

    See identical proteins and their annotated locations for XP_005269565.1

    Conserved Domains (1) summary
    cd15723
    Location:275335
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  2. XM_005269509.3XP_005269566.1  protrudin isoform X15

    See identical proteins and their annotated locations for XP_005269566.1

    Conserved Domains (1) summary
    cd15723
    Location:275335
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  3. XM_011539254.2XP_011537556.1  protrudin isoform X13

    See identical proteins and their annotated locations for XP_011537556.1

    Conserved Domains (1) summary
    cd15723
    Location:286346
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  4. XM_011539253.2XP_011537555.1  protrudin isoform X6

    Conserved Domains (1) summary
    cd15723
    Location:347389
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  5. XM_011539252.2XP_011537554.1  protrudin isoform X5

    Conserved Domains (1) summary
    cd15723
    Location:354396
    FYVE_protrudin; FYVE-related domain found in protrudin and similar proteins
  6. XM_017015644.1XP_016871133.1  protrudin isoform X7

  7. XM_017015645.1XP_016871134.1  protrudin isoform X8

  8. XM_017015646.1XP_016871135.1  protrudin isoform X9

    UniProtKB/TrEMBL
    B7Z6J9

RNA

  1. XR_002956957.1 RNA Sequence

  2. XR_945597.2 RNA Sequence

  3. XR_002956956.1 RNA Sequence

  4. XR_945594.2 RNA Sequence

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