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GPR62 G protein-coupled receptor 62 [ Homo sapiens (human) ]

Gene ID: 118442, updated on 22-Sep-2022

Summary

Official Symbol
GPR62provided by HGNC
Official Full Name
G protein-coupled receptor 62provided by HGNC
Primary source
HGNC:HGNC:13301
See related
Ensembl:ENSG00000180929 MIM:606917; AllianceGenome:HGNC:13301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR8; KPG_005
Summary
Enables arrestin family protein binding activity. Involved in G protein-coupled receptor signaling pathway; inositol phosphate-mediated signaling; and positive regulation of cAMP-mediated signaling. Located in endosome and plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See GPR62 in Genome Data Viewer
Location:
3p21.2
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (51955381..51957499)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (51988300..51990418)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (51989397..51991515)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene poly(ADP-ribose) polymerase family member 3 Neighboring gene poly(rC) binding protein 4 Neighboring gene abhydrolase domain containing 14B Neighboring gene ABHD14A-ACY1 readthrough Neighboring gene Sharpr-MPRA regulatory region 207 Neighboring gene abhydrolase domain containing 14A

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC26943

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arrestin family protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein coupled receptor 62
Names
G-protein coupled receptor GPCR8
G-protein coupled receptor KPG_005
hGPCR8
probable G-protein coupled receptor 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080865.4NP_543141.3  G-protein coupled receptor 62

    See identical proteins and their annotated locations for NP_543141.3

    Status: VALIDATED

    Source sequence(s)
    AC115284, BC026357
    Consensus CDS
    CCDS2838.1
    UniProtKB/Swiss-Prot
    Q5KU27, Q9BZJ7
    UniProtKB/TrEMBL
    Q8TAM0
    Related
    ENSP00000319250.4, ENST00000322241.6
    Conserved Domains (1) summary
    pfam00001
    Location:31290
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    51955381..51957499
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    51988300..51990418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)