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Arf4 ADP-ribosylation factor 4 [ Mus musculus (house mouse) ]

Gene ID: 11843, updated on 18-Apr-2024

Summary

Official Symbol
Arf4provided by MGI
Official Full Name
ADP-ribosylation factor 4provided by MGI
Primary source
MGI:MGI:99433
See related
Ensembl:ENSMUSG00000021877 AllianceGenome:MGI:99433
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity and epidermal growth factor receptor binding activity. Involved in regulation of postsynapse organization. Acts upstream of or within several processes, including apical protein localization; dendritic spine development; and establishment or maintenance of epithelial cell apical/basal polarity. Located in Golgi apparatus; glutamatergic synapse; and plasma membrane. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and skeleton. Orthologous to human ARF4 (ADP ribosylation factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 186.8), duodenum adult (RPKM 168.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
14 A3; 14 16.09 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (26359289..26377997)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (26638134..26656842)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8 pseudogene Neighboring gene DENN domain containing 6A Neighboring gene STARR-seq mESC enhancer starr_36241 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:27489365-27489548 Neighboring gene phosphodiesterase 12 Neighboring gene microRNA 7672 Neighboring gene dynein, axonemal, heavy chain 12 Neighboring gene predicted gene, 34415

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Gene trapped (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables NAD+-protein-arginine ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase D activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein localization to cilium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ADP-ribosylation factor 4
NP_031505.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007479.4NP_031505.1  ADP-ribosylation factor 4

    See identical proteins and their annotated locations for NP_031505.1

    Status: VALIDATED

    Source sequence(s)
    AC121919, AK081686, AK168793, AU080387
    Consensus CDS
    CCDS26881.1
    UniProtKB/Swiss-Prot
    P36403, P61750, Q3TGC2, Q9CXX3
    UniProtKB/TrEMBL
    Q14BR4, Q9DD04
    Related
    ENSMUSP00000022429.3, ENSMUST00000022429.9
    Conserved Domains (1) summary
    cl40481
    Location:1180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    26359289..26377997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)