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UBE2J2 ubiquitin conjugating enzyme E2 J2 [ Homo sapiens (human) ]

Gene ID: 118424, updated on 12-May-2019

Summary

Official Symbol
UBE2J2provided by HGNC
Official Full Name
ubiquitin conjugating enzyme E2 J2provided by HGNC
Primary source
HGNC:HGNC:19268
See related
Ensembl:ENSG00000160087
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCUBE2; NCUBE-2; PRO2121
Summary
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 15.7), fat (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See UBE2J2 in Genome Data Viewer
Location:
1p36.33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (1253912..1273854, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1189292..1209234, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene beta-1,3-galactosyltransferase 6 Neighboring gene C1q and TNF related 12 Neighboring gene long intergenic non-protein coding RNA 1786 Neighboring gene sodium channel epithelial 1 delta subunit Neighboring gene CEB15 minisatellite repeat instability region

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
    Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
  • Parkinson's disease, organism-specific biosystem (from KEGG)
    Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
  • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
    Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
  • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
    Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • protein ubiquitylation, organism-specific biosystem (from BIOCYC)
    protein ubiquitylation, organism-specific biosystem
    protein ubiquitylation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin conjugating enzyme activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein targeting to mitochondrion HMP PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
response to unfolded protein IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
ubiquitin-conjugating enzyme E2 J2
Names
E2 ubiquitin-conjugating enzyme J2
non-canonical ubiquitin-conjugating enzyme 2
ubiquitin conjugating enzyme 6
ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast)
yeast UBC6 homolog
NP_477515.2
NP_919296.1
NP_919439.1
NP_919440.1
XP_005244775.1
XP_005244776.1
XP_006710396.1
XP_011538915.1
XP_011538916.1
XP_011538918.1
XP_011538919.1
XP_016855727.1
XP_016855728.1
XP_024308790.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058167.2NP_477515.2  ubiquitin-conjugating enzyme E2 J2 isoform 2

    See identical proteins and their annotated locations for NP_477515.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame internal exon, as compared to variant 1. The encoded isoform (2) is thus missing an internal segment, as compared to isoform 1.
    Source sequence(s)
    AK056065, AK098803, BE515187, BG499172, BG717336, BQ881730
    Consensus CDS
    CCDS14.1
    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A0A024R075
    Related
    ENSP00000305826.6, ENST00000349431.10
    Conserved Domains (1) summary
    cd00195
    Location:14127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. NM_194315.1NP_919296.1  ubiquitin-conjugating enzyme E2 J2 isoform 1

    See identical proteins and their annotated locations for NP_919296.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK098803, AW411508, BE382927, BE515187, BG717336, BM544827
    Consensus CDS
    CCDS15.1
    UniProtKB/Swiss-Prot
    Q8N2K1
    Related
    ENSP00000383719.4, ENST00000400930.8
    Conserved Domains (1) summary
    cd00195
    Location:14143
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. NM_194457.1NP_919439.1  ubiquitin-conjugating enzyme E2 J2 isoform 3

    See identical proteins and their annotated locations for NP_919439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive internal exons, as compared to variant 1. It uses a downstream start codon, so the encoded isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK098803, BE515187, BG112933, BG717336, BM765278
    Consensus CDS
    CCDS16.1
    UniProtKB/TrEMBL
    A6NGS0
    Related
    ENSP00000383718.2, ENST00000400929.6
    Conserved Domains (1) summary
    cd00195
    Location:275
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. NM_194458.1NP_919440.1  ubiquitin-conjugating enzyme E2 J2 isoform 3

    See identical proteins and their annotated locations for NP_919440.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has two alternate splice sites in the 5' region, as compared to variant 1. It uses a downstream start codon, so the encoded isoform (3) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK075017, AK098803, BE515187, BG717336, BM926567
    Consensus CDS
    CCDS16.1
    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A6NGS0
    Related
    ENSP00000344857.2, ENST00000347370.6
    Conserved Domains (1) summary
    cd00195
    Location:275
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    1253912..1273854 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244719.4XP_005244776.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_005244776.1

    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A0A024R075
    Related
    ENSP00000353653.2, ENST00000360466.6
    Conserved Domains (1) summary
    cd00195
    Location:14127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  2. XM_017000238.1XP_016855727.1  ubiquitin-conjugating enzyme E2 J2 isoform X4

    Conserved Domains (1) summary
    cd00195
    Location:675
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  3. XM_011540616.2XP_011538918.1  ubiquitin-conjugating enzyme E2 J2 isoform X4

    See identical proteins and their annotated locations for XP_011538918.1

    Conserved Domains (1) summary
    cd00195
    Location:675
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  4. XM_005244718.3XP_005244775.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_005244775.1

    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A0A024R075
    Conserved Domains (1) summary
    cd00195
    Location:14127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  5. XM_024453022.1XP_024308790.1  ubiquitin-conjugating enzyme E2 J2 isoform X1

    Conserved Domains (1) summary
    cd00195
    Location:78160
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  6. XM_006710333.3XP_006710396.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_006710396.1

    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A0A024R075
    Conserved Domains (1) summary
    cd00195
    Location:14127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  7. XM_011540614.2XP_011538916.1  ubiquitin-conjugating enzyme E2 J2 isoform X2

    See identical proteins and their annotated locations for XP_011538916.1

    UniProtKB/Swiss-Prot
    Q8N2K1
    UniProtKB/TrEMBL
    A0A024R075
    Conserved Domains (1) summary
    cd00195
    Location:14127
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  8. XM_011540617.3XP_011538919.1  ubiquitin-conjugating enzyme E2 J2 isoform X4

    See identical proteins and their annotated locations for XP_011538919.1

    Conserved Domains (1) summary
    cd00195
    Location:675
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  9. XM_011540613.3XP_011538915.1  ubiquitin-conjugating enzyme E2 J2 isoform X3

    See identical proteins and their annotated locations for XP_011538915.1

    UniProtKB/Swiss-Prot
    Q8N2K1
    Conserved Domains (1) summary
    cd00195
    Location:1092
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
  10. XM_017000239.2XP_016855728.1  ubiquitin-conjugating enzyme E2 J2 isoform X5

    UniProtKB/TrEMBL
    A6NGS0
    Conserved Domains (1) summary
    cd00195
    Location:275
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194316.1: Suppressed sequence

    Description
    NM_194316.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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