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LINC00161 long intergenic non-protein coding RNA 161 [ Homo sapiens (human) ]

Gene ID: 118421, updated on 3-Mar-2026
Official Symbol
LINC00161provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 161provided by HGNC
Primary source
HGNC:HGNC:17138
See related
Ensembl:ENSG00000226935 AllianceGenome:HGNC:17138
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HORAS5; C21orf100; Linc-USP16; NCRNA00161
Expression
Restricted expression toward prostate (RPKM 1.4) See more
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Try the new Transcripts and proteins table
See LINC00161 in Genome Data Viewer
Location:
21q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (28539318..28540355)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (26902245..26903282)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (29911640..29912677)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:29390498-29390664 Neighboring gene long intergenic non-protein coding RNA 314 Neighboring gene long intergenic non-protein coding RNA 1697 Neighboring gene long intergenic non-protein coding RNA 1695 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr21:29697851-29698465 Neighboring gene HemK methyltransferase 2, ETF1 glutamine and histone H4 lysine Neighboring gene uncharacterized LOC124905067 Neighboring gene Sharpr-MPRA regulatory region 7516 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18322 Neighboring gene MPRA-validated peak4395 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:30206496-30207695 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:30228725-30229226 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:30229227-30229726 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr21:30256988-30257547 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr21:30257548-30258106 Neighboring gene heat shock protein family D (Hsp60) member 1 pseudogene 7

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression. Sui J, et al. Cell Physiol Biochem, 2017. PMID 29179215
  2. LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism. Pucci P, et al. Epigenomics, 2020 Jul. PMID 32618200
  3. The long noncoding RNA HORAS5 mediates castration-resistant prostate cancer survival by activating the androgen receptor transcriptional program. Parolia A, et al. Mol Oncol, 2019 May. PMID 30776192, Free PMC Article
  4. Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. You LN, et al. Cancer Gene Ther, 2021 Jun. PMID 33414518
  5. Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1. Xu M, et al. Mol Carcinog, 2019 Apr. PMID 30556928

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma.
    Title: Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma.
  2. LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.
    Title: LncRNA HORAS5 promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.
  3. High LINC00161 expression is associated with drug resistance in ovarian cancer.
    Title: Linc00161 regulated the drug resistance of ovarian cancer by sponging microRNA-128 and modulating MAPK1.
  4. Linc-USP16 suppressed AKT pathway activation via regulation of PTEN expression in a transcription-independent manner.
    Title: Long Non-Coding RNA Linc-USP16 Functions As a Tumour Suppressor in Hepatocellular Carcinoma by Regulating PTEN Expression.
  5. LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance.
    Title: Long non-coding RNA LINC00161 sensitises osteosarcoma cells to cisplatin-induced apoptosis by regulating the miR-645-IFIT2 axis.
Submit: New GeneRIF Correction

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Markers

Clone Names

  • MGC125397, MGC125398, MGC125399, MGC125400

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026552.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF165147
    Related
    ENST00000412526.5

  2. NR_026553.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, resulting in a shorter transcript, compared to variant 1.
    Source sequence(s)
    AF165147
    Related
    ENST00000455939.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    28539318..28540355
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    26902245..26903282
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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