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Aqp7 aquaporin 7 [ Mus musculus (house mouse) ]

Gene ID: 11832, updated on 1-Mar-2024

Summary

Official Symbol
Aqp7provided by MGI
Official Full Name
aquaporin 7provided by MGI
Primary source
MGI:MGI:1314647
See related
Ensembl:ENSMUSG00000028427 AllianceGenome:MGI:1314647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AQP7L; AQPap
Summary
Predicted to enable glycerol channel activity; urea channel activity; and water channel activity. Acts upstream of or within glycerol transport and renal water absorption. Is integral component of plasma membrane. Colocalizes with lipid droplet. Is expressed in early conceptus; gonad; liver; and metanephros. Orthologous to several human genes including AQP7 (aquaporin 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 55.7), subcutaneous fat pad adult (RPKM 41.1) and 7 other tissues See more
Orthologs
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Genomic context

See Aqp7 in Genome Data Viewer
Location:
4 A5; 4 20.83 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41033074..41048237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41033074..41048237, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E3485 Neighboring gene predicted gene, 52692 Neighboring gene nuclear transcription factor, X-box binding 1 Neighboring gene microRNA 3094 Neighboring gene predicted gene, 25637 Neighboring gene aquaporin 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
 
enables glycerol channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycerol channel activity ISO
Inferred from Sequence Orthology
more info
 
enables urea channel activity ISO
Inferred from Sequence Orthology
more info
 
enables urea transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables water channel activity ISO
Inferred from Sequence Orthology
more info
 
enables water channel activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in glycerol transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glycerol transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glycerol transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within renal water absorption IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in urea transport ISO
Inferred from Sequence Orthology
more info
 
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in water transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within water transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aquaporin-7
Names
AQP-7
aquaglyceroporin-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378638.1NP_001365567.1  aquaporin-7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL837521
    Conserved Domains (1) summary
    cl00200
    Location:18232
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  2. NM_001378639.1NP_001365568.1  aquaporin-7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL837521
    UniProtKB/Swiss-Prot
    O54794, Q8C630
    UniProtKB/TrEMBL
    Q5DX24
    Related
    ENSMUSP00000093007.4, ENSMUST00000054945.8
    Conserved Domains (1) summary
    cl00200
    Location:18265
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  3. NM_001378640.1NP_001365569.1  aquaporin-7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL837521
    Conserved Domains (1) summary
    cl00200
    Location:44202
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  4. NM_001378641.1NP_001365570.1  aquaporin-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL837521
    Conserved Domains (1) summary
    cl00200
    Location:44235
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  5. NM_001378642.1NP_001365571.1  aquaporin-7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL837521
    Conserved Domains (1) summary
    cl00200
    Location:44235
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  6. NM_007473.4NP_031499.1  aquaporin-7 isoform 2

    See identical proteins and their annotated locations for NP_031499.1

    Status: VALIDATED

    Source sequence(s)
    AK131744, AL837521, BU945845
    Consensus CDS
    CCDS18055.1
    UniProtKB/Swiss-Prot
    O54794, Q8C630
    UniProtKB/TrEMBL
    Q5DX24
    Related
    ENSMUSP00000030136.7, ENSMUST00000030136.13
    Conserved Domains (1) summary
    cl00200
    Location:18265
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    41033074..41048237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537560.5XP_006537623.2  aquaporin-7 isoform X2

    See identical proteins and their annotated locations for XP_006537623.2

    UniProtKB/Swiss-Prot
    O54794, Q8C630
    UniProtKB/TrEMBL
    Q5DX24
    Conserved Domains (1) summary
    cl00200
    Location:18265
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  2. XM_006537559.5XP_006537622.2  aquaporin-7 isoform X1

    See identical proteins and their annotated locations for XP_006537622.2

    Conserved Domains (1) summary
    cl00200
    Location:18232
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  3. XM_006537563.2XP_006537626.1  aquaporin-7 isoform X1

    See identical proteins and their annotated locations for XP_006537626.1

    Conserved Domains (1) summary
    cl00200
    Location:18232
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  4. XM_030253099.2XP_030108959.1  aquaporin-7 isoform X1

    Conserved Domains (1) summary
    cl00200
    Location:18232
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  5. XM_036163606.1XP_036019499.1  aquaporin-7 isoform X3

    Conserved Domains (1) summary
    cl00200
    Location:20179
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  6. XM_017319925.2XP_017175414.1  aquaporin-7 isoform X4