U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aprt adenine phosphoribosyl transferase [ Mus musculus (house mouse) ]

Gene ID: 11821, updated on 27-Nov-2024

Summary

Official Symbol
Aprtprovided by MGI
Official Full Name
adenine phosphoribosyl transferaseprovided by MGI
Primary source
MGI:MGI:88061
See related
Ensembl:ENSMUSG00000006589 AllianceGenome:MGI:88061
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables adenine binding activity and adenine phosphoribosyltransferase activity. Involved in AMP salvage; GMP salvage; and IMP salvage. Acts upstream of or within adenine metabolic process; grooming behavior; and purine ribonucleoside salvage. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; cranium; genitourinary system; and sensory organ. Used to study adenine phosphoribosyltransferase deficiency. Human ortholog(s) of this gene implicated in adenine phosphoribosyltransferase deficiency. Orthologous to human APRT (adenine phosphoribosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 258.1), placenta adult (RPKM 212.8) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aprt in Genome Data Viewer
Location:
8 E1; 8 71.91 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123301376..123303646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122574637..122576907, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:125080544-125080815 Neighboring gene predicted gene, 34847 Neighboring gene STARR-positive B cell enhancer ABC_E8270 Neighboring gene chromatin licensing and DNA replication factor 1 Neighboring gene galactosamine (N-acetyl)-6-sulfatase Neighboring gene predicted gene, 34962 Neighboring gene 60S ribosomal protein L30 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC11749

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables adenine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables adenine phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenine phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables adenine phosphoribosyltransferase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables adenine phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables adenine phosphoribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in AMP salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in AMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in AMP salvage IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within AMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in AMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in GMP salvage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in IMP salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adenine metabolic process IC
Inferred by Curator
more info
PubMed 
acts_upstream_of_or_within adenine metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within adenine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenine salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenine salvage IEA
Inferred from Electronic Annotation
more info
 
NOT acts_upstream_of_or_within grooming behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within grooming behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lactation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within purine ribonucleoside salvage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within purine ribonucleoside salvage IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
adenine phosphoribosyltransferase
NP_033828.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009698.2NP_033828.2  adenine phosphoribosyltransferase

    See identical proteins and their annotated locations for NP_033828.2

    Status: VALIDATED

    Source sequence(s)
    AK153201, BY115322
    Consensus CDS
    CCDS40503.1
    UniProtKB/Swiss-Prot
    P08030, Q564P4, Q61319, Q6PK77, Q9DCY3
    Related
    ENSMUSP00000006764.8, ENSMUST00000006764.9
    Conserved Domains (1) summary
    PRK02304
    Location:6180
    PRK02304; adenine phosphoribosyltransferase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123301376..123303646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)