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Aplp2 amyloid beta precursor-like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 11804, updated on 1-Mar-2024

Summary

Official Symbol
Aplp2provided by MGI
Official Full Name
amyloid beta precursor-like protein 2provided by MGI
Primary source
MGI:MGI:88047
See related
Ensembl:ENSMUSG00000031996 AllianceGenome:MGI:88047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDEBP; APLP-2
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Predicted to be located in nucleus. Is expressed in several structures, including axial musculature; compacted morula; lower urinary tract; submandibular gland primordium; and ventral grey horn. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 233.8), bladder adult (RPKM 222.5) and 28 other tissues See more
Orthologs
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Genomic context

See Aplp2 in Genome Data Viewer
Location:
9 A4; 9 16.66 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31060853..31123144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31149557..31211848, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene predicted gene, 17508 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene STARR-seq mESC enhancer starr_23691 Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535 Neighboring gene STARR-positive B cell enhancer ABC_E3820 Neighboring gene STARR-seq mESC enhancer starr_23693 Neighboring gene predicted gene, 53544 Neighboring gene predicted gene 7244 Neighboring gene predicted gene, 51733

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within suckling behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in spine apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in spine apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
amyloid beta precursor like protein 2
Names
CDE1-binding protein CDEBP
CDEI box-binding protein
amyloid beta (A4) precursor-like protein 2
amyloid protein homolog
amyloid-like protein 2
sperm membrane protein YWK-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102455.2NP_001095925.1  amyloid beta precursor like protein 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001095925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AK150020, BC052396, BY304295, CT025678
    Consensus CDS
    CCDS52749.1
    UniProtKB/TrEMBL
    Q3UDL6, Q60709
    Related
    ENSMUSP00000072428.8, ENSMUST00000072634.15
    Conserved Domains (6) summary
    smart00006
    Location:42204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:49147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:697747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:365547
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001102456.2NP_001095926.1  amyloid beta precursor like protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001095926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AC114542, BC051999, BY304295
    Consensus CDS
    CCDS52748.1
    UniProtKB/Swiss-Prot
    Q06335, Q80US7
    UniProtKB/TrEMBL
    Q7TT34
    Related
    ENSMUSP00000078694.8, ENSMUST00000079758.9
    Conserved Domains (5) summary
    smart00006
    Location:42204
    A4_EXTRA; amyloid A4
    pfam02177
    Location:49147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:653703
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:309491
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001357698.1NP_001344627.1  amyloid beta precursor like protein 2 isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC114542, CT025678
    UniProtKB/TrEMBL
    Q3UDL6, Q61482
    Related
    ENSMUSP00000149732.2, ENSMUST00000213254.2
    Conserved Domains (4) summary
    smart00006
    Location:42204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:709759
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365547
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_009691.3NP_033821.1  amyloid beta precursor like protein 2 isoform c precursor

    See identical proteins and their annotated locations for NP_033821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AC114542, BC052396, BY304295
    Consensus CDS
    CCDS90528.1
    UniProtKB/TrEMBL
    Q64348, Q7TT34
    Related
    ENSMUSP00000149023.2, ENSMUST00000217641.2
    Conserved Domains (5) summary
    smart00006
    Location:42204
    A4_EXTRA; amyloid A4
    pfam02177
    Location:49147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:641691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:309491
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31060853..31123144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509952.1XP_006510015.1  amyloid beta precursor like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3UDL6
    Conserved Domains (4) summary
    smart00006
    Location:1151
    A4_EXTRA; amyloid A4
    pfam00014
    Location:256307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:656706
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:312494
    APP_E2; E2 domain of amyloid precursor protein