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Aplp2 amyloid beta precursor-like protein 2 [ Mus musculus (house mouse) ]

Gene ID: 11804, updated on 2-Nov-2024

Summary

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Official Symbol
Aplp2provided by MGI
Official Full Name
amyloid beta precursor-like protein 2provided by MGI
Primary source
MGI:MGI:88047
See related
Ensembl:ENSMUSG00000031996 AllianceGenome:MGI:88047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CDEBP; APLP-2
Summary
Predicted to enable identical protein binding activity and serine-type endopeptidase inhibitor activity. Acts upstream of or within several processes, including brain development; regulation of epidermal growth factor-activated receptor activity; and suckling behavior. Is active in spine apparatus. Is expressed in several structures, including compacted morula; heart; lower urinary tract; submandibular gland primordium; and ventral grey horn. Orthologous to human APLP2 (amyloid beta precursor like protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 233.8), bladder adult (RPKM 222.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aplp2 in Genome Data Viewer
Location:
9 A4; 9 16.66 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (31060853..31123144, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (31149557..31211848, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 44 Neighboring gene predicted gene, 17508 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene suppression of tumorigenicity 14 (colon carcinoma) Neighboring gene STARR-seq mESC enhancer starr_23691 Neighboring gene protein CEBPZOS pseudogene Neighboring gene predicted gene, 33535 Neighboring gene STARR-positive B cell enhancer ABC_E3820 Neighboring gene STARR-seq mESC enhancer starr_23693 Neighboring gene predicted gene, 53544 Neighboring gene predicted gene 7244 Neighboring gene predicted gene, 51733

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A murine sequence-specific DNA binding protein shows extensive local similarities to the amyloid precursor protein. Vidal F, et al. Biochem Biophys Res Commun, 1992 Dec 30. PMID 1482349
  2. Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics. Dinet V, et al. Mol Brain, 2016 Jun 8. PMID 27267879, Free PMC Article
  3. Delineation of the functional domains of the extracellular region of YWK-II Protein/APLP2 of sperm membrane. Zhuang D, et al. Front Biosci, 2006 Sep 1. PMID 16720320
  4. YWK-II protein/APLP2 in mouse gametes: potential role in fertilization. Zhuang D, et al. Mol Reprod Dev, 2006 Jan. PMID 16177981
  5. The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Korte M, et al. Exp Brain Res, 2012 Apr. PMID 22006270

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
    Title: Mycobacterium tuberculosis suppresses APLP2 expression to enhance its survival in macrophage.
  2. Presenilin and APP Regulate Synaptic Kainate Receptors.
    Title: Presenilin and APP Regulate Synaptic Kainate Receptors.
  3. Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.
    Title: Reduced expression of APLP2 in spinal GABAergic inhibitory neurons contributed to nerve injury-induced microglial activation and pain sensitization.
  4. Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
    Title: Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.
  5. APPsalpha rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons.
    Title: APPsα rescues impaired Ca(2+) homeostasis in APP- and APLP2-deficient hippocampal neurons.
  6. Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
    Title: Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.
  7. Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
    Title: Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND.
  8. These data identified APP and APLP2 as modulators of normal myelination and demyelination/remyelination conditions.
    Title: Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.
  9. APLP2 couples retina development and synaptic genes and present the first evidence that APLP2 expression may be linked to synaptic disease.
    Title: Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics.
  10. These data support the notion that APP and APLP2 facilitate transmitter release, likely through the interaction with the neurotransmitter release machinery.
    Title: APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (7)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within embryo development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within mating behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of protein binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within suckling behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in spine apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in spine apparatus IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
amyloid beta precursor like protein 2
Names
CDE1-binding protein CDEBP
CDEI box-binding protein
amyloid beta (A4) precursor-like protein 2
amyloid protein homolog
amyloid-like protein 2
sperm membrane protein YWK-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102455.2 → NP_001095925.1  amyloid beta precursor like protein 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001095925.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (a) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AK150020, BC052396, BY304295, CT025678
    Consensus CDS
    CCDS52749.1
    UniProtKB/TrEMBL
    Q3UDL6, Q60709
    Related
    ENSMUSP00000072428.8, ENSMUST00000072634.15
    Conserved Domains (6) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:697 → 747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein

  2. NM_001102456.2 → NP_001095926.1  amyloid beta precursor like protein 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001095926.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 4. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AC114542, BC051999, BY304295
    Consensus CDS
    CCDS52748.1
    UniProtKB/Swiss-Prot
    Q06335, Q80US7
    UniProtKB/TrEMBL
    Q7TT34
    Related
    ENSMUSP00000078694.8, ENSMUST00000079758.9
    Conserved Domains (5) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:653 → 703
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein

  3. NM_001357698.1 → NP_001344627.1  amyloid beta precursor like protein 2 isoform d precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (d).
    Source sequence(s)
    AC114542, CT025678
    UniProtKB/TrEMBL
    Q3UDL6, Q61482
    Related
    ENSMUSP00000149732.2, ENSMUST00000213254.2
    Conserved Domains (4) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam00014
    Location:309 → 361
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:709 → 759
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:365 → 547
    APP_E2; E2 domain of amyloid precursor protein

  4. NM_009691.3 → NP_033821.1  amyloid beta precursor like protein 2 isoform c precursor

    See identical proteins and their annotated locations for NP_033821.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 4. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform d.
    Source sequence(s)
    AC114542, BC052396, BY304295
    Consensus CDS
    CCDS90528.1
    UniProtKB/TrEMBL
    Q64348, Q7TT34
    Related
    ENSMUSP00000149023.2, ENSMUST00000217641.2
    Conserved Domains (5) summary
    smart00006
    Location:42 → 204
    A4_EXTRA; amyloid A4
    pfam02177
    Location:49 → 147
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam10515
    Location:641 → 691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:149 → 204
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:309 → 491
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    31060853..31123144 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509952.1 → XP_006510015.1  amyloid beta precursor like protein 2 isoform X1

    UniProtKB/TrEMBL
    Q3UDL6
    Conserved Domains (4) summary
    smart00006
    Location:1 → 151
    A4_EXTRA; amyloid A4
    pfam00014
    Location:256 → 307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam10515
    Location:656 → 706
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:312 → 494
    APP_E2; E2 domain of amyloid precursor protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06335.4 GenPept UniProtKB/Swiss-Prot:Q06335

Gene LinkOut

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