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Apex1 apurinic/apyrimidinic endonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 11792, updated on 8-Jul-2018
Official Symbol
Apex1provided by MGI
Official Full Name
apurinic/apyrimidinic endonuclease 1provided by MGI
Primary source
MGI:MGI:88042
See related
Ensembl:ENSMUSG00000035960 Vega:OTTMUSG00000019767
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APE; Apex; HAP1; Ref-1
Expression
Ubiquitous expression in CNS E11.5 (RPKM 76.3), CNS E14 (RPKM 49.8) and 27 other tissues See more
Orthologs
See Apex1 in Genome Data Viewer
Location:
14 C1; 14 26.3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (50924949..50927188)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (51544696..51546813)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene kelch-like 33 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene purine-nucleoside phosphorylase

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
DNA binding ISO
Inferred from Sequence Orthology
more info
 
DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
double-stranded DNA 3'-5' exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-stranded DNA exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
endoribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding ISO
Inferred from Sequence Orthology
more info
 
nuclease activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
phosphodiesterase I activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
site-specific endodeoxyribonuclease activity, specific for altered base ISO
Inferred from Sequence Orthology
more info
 
transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
DNA recombination IEA
Inferred from Electronic Annotation
more info
 
DNA repair ISO
Inferred from Sequence Orthology
more info
 
aging ISO
Inferred from Sequence Orthology
more info
 
base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
base-excision repair ISO
Inferred from Sequence Orthology
more info
 
cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
telomere maintenance via base-excision repair ISO
Inferred from Sequence Orthology
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear speck ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
DNA-(apurinic or apyrimidinic site) lyase
Names
AP endonuclease 1
APEN
APEX nuclease
redox factor-1
NP_033817.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009687.2NP_033817.1  DNA-(apurinic or apyrimidinic site) lyase

    See identical proteins and their annotated locations for NP_033817.1

    Status: VALIDATED

    Source sequence(s)
    AC027184, BC052401
    Consensus CDS
    CCDS27027.1
    UniProtKB/Swiss-Prot
    P28352
    UniProtKB/TrEMBL
    Q544Z7
    Related
    ENSMUSP00000042602.5, OTTMUSP00000021336, ENSMUST00000049411.11, OTTMUST00000047275
    Conserved Domains (1) summary
    cd09087
    Location:61315
    Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    50924949..50927188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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