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Apex1 apurinic/apyrimidinic endonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 11792, updated on 29-Jan-2023

Summary

Official Symbol
Apex1provided by MGI
Official Full Name
apurinic/apyrimidinic endonuclease 1provided by MGI
Primary source
MGI:MGI:88042
See related
Ensembl:ENSMUSG00000035960 AllianceGenome:MGI:88042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APE; Apex; HAP1; Ref-1
Summary
Predicted to enable several functions, including DNA binding activity; NF-kappaB binding activity; and nuclease activity. Acts upstream of or within cell redox homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; autopod; musculoskeletal system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; female reproductive organ cancer (multiple); spina bifida; and urinary bladder cancer. Orthologous to human APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 76.3), CNS E14 (RPKM 49.8) and 27 other tissues See more
Orthologs
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Genomic context

See Apex1 in Genome Data Viewer
Location:
14 C1; 14 26.3 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51162406..51164645)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (50924949..50927188)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene kelch-like 33 Neighboring gene O-sialoglycoprotein endopeptidase Neighboring gene Apex1 promoter region Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene predicted gene, 52117 Neighboring gene purine-nucleoside phosphorylase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables 3'-5'-DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-(abasic site) binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables class II DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA 3'-5' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables double-stranded DNA exodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded telomeric DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands ISO
Inferred from Sequence Orthology
more info
 
enables phosphoric diester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoric diester hydrolase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables site-specific endodeoxyribonuclease activity, specific for altered base ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in DNA catabolic process, endonucleolytic ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA demethylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within DNA recombination IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
involved_in base-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in base-excision repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell redox homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in telomere maintenance via base-excision repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA-(apurinic or apyrimidinic site) endonuclease
Names
AP endonuclease 1
APEN
APEX nuclease
DNA-(apurinic or apyrimidinic site) lyase
redox factor-1
NP_033817.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009687.2NP_033817.1  DNA-(apurinic or apyrimidinic site) endonuclease

    See identical proteins and their annotated locations for NP_033817.1

    Status: VALIDATED

    Source sequence(s)
    AC027184, BC052401
    Consensus CDS
    CCDS27027.1
    UniProtKB/Swiss-Prot
    P28352
    UniProtKB/TrEMBL
    Q544Z7
    Related
    ENSMUSP00000042602.6, ENSMUST00000049411.12
    Conserved Domains (1) summary
    cd09087
    Location:61315
    Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    51162406..51164645
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)