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CLC Charcot-Leyden crystal galectin [ Homo sapiens (human) ]

Gene ID: 1178, updated on 7-Dec-2018

Summary

Official Symbol
CLCprovided by HGNC
Official Full Name
Charcot-Leyden crystal galectinprovided by HGNC
Primary source
HGNC:HGNC:2014
See related
Ensembl:ENSG00000105205 MIM:153310
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAL10; Gal-10; LGALS10; LGALS10A; LPPL_HUMAN
Summary
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene is a lysophospholipase expressed in eosinophils and basophils. It hydrolyzes lysophosphatidylcholine to glycerophosphocholine and a free fatty acid. This protein may possess carbohydrate or IgE-binding activities. It is both structurally and functionally related to the galectin family of beta-galactoside binding proteins. It may be associated with inflammation and some myeloid leukemias. [provided by RefSeq, Jul 2008]
Expression
Biased expression in bone marrow (RPKM 112.7), urinary bladder (RPKM 16.5) and 5 other tissues See more
Orthologs

Genomic context

See CLC in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (39731253..39738029, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40221893..40228669, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein S29 pseudogene 27 Neighboring gene galectin 14 Neighboring gene leucine twenty homeobox Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 1B Neighboring gene microRNA 6719

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC149659

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT contributes_to lysophospholipase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
regulation of T cell anergy IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of T cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
galectin-10
Names
Charcot-Leyden crystal protein
eosinophil lysophospholipase
lectin, galactoside-binding, soluble, 10
lysolecithin acylhydrolase
NP_001819.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046978.1 RefSeqGene

    Range
    5001..11777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001828.6NP_001819.2  galectin-10

    See identical proteins and their annotated locations for NP_001819.2

    Status: REVIEWED

    Source sequence(s)
    AV715261, AV762486, AW292557
    Consensus CDS
    CCDS33025.1
    UniProtKB/Swiss-Prot
    Q05315
    Related
    ENSP00000221804.3, ENST00000221804.4
    Conserved Domains (1) summary
    pfam00337
    Location:5137
    Gal-bind_lectin; Galactoside-binding lectin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    39731253..39738029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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