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Ap3s2 adaptor-related protein complex 3, sigma 2 subunit [ Mus musculus (house mouse) ]

Gene ID: 11778, updated on 12-May-2024

Summary

Official Symbol
Ap3s2provided by MGI
Official Full Name
adaptor-related protein complex 3, sigma 2 subunitprovided by MGI
Primary source
MGI:MGI:1337060
See related
Ensembl:ENSMUSG00000063801 AllianceGenome:MGI:1337060
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
[s]3B
Summary
Involved in anterograde synaptic vesicle transport. Predicted to be located in trans-Golgi network. Predicted to be part of AP-3 adaptor complex. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human AP3S2 (adaptor related protein complex 3 subunit sigma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 17.2), CNS E14 (RPKM 15.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ap3s2 in Genome Data Viewer
Location:
7 D2; 7 45.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79525073..79570388, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (79875325..79920640, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene mesoderm posterior 2 Neighboring gene alanyl aminopeptidase, membrane Neighboring gene STARR-seq mESC enhancer starr_19292 Neighboring gene RIKEN cDNA 5430400D12 gene Neighboring gene actin-related protein 2/3 complex inhibitor Neighboring gene predicted gene, 31966

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
part_of AP-3 adaptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of AP-3 adaptor complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of membrane coat IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
AP-3 complex subunit sigma-2
Names
AP-3 complex sigma-3B subunit
AP-3 complex subunit sigma-3B
adapter-related protein complex 3 sigma-2 subunit
adapter-related protein complex 3 subunit sigma-2
adaptor-related protein complex 3 subunit sigma-2
adaptor-related protein complex AP-3, sigma 2 subunit
sigma 3B
sigma-3B-adaptin
sigma-adaptin 3b
sigma3B-adaptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009682.3NP_033812.3  AP-3 complex subunit sigma-2

    See identical proteins and their annotated locations for NP_033812.3

    Status: VALIDATED

    Source sequence(s)
    AC109221, AK150085, BC060236, BY127127
    Consensus CDS
    CCDS21389.1
    UniProtKB/Swiss-Prot
    Q3UDG7, Q8BSZ2, Q8CAY1
    UniProtKB/TrEMBL
    Q6PAL3
    Related
    ENSMUSP00000075082.7, ENSMUST00000075657.8
    Conserved Domains (1) summary
    cd14834
    Location:1146
    AP3_sigma; AP-3 complex subunit sigma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    79525073..79570388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)