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Prdx6 peroxiredoxin 6 [ Mus musculus (house mouse) ]

Gene ID: 11758, updated on 8-Feb-2024

Summary

Official Symbol
Prdx6provided by MGI
Official Full Name
peroxiredoxin 6provided by MGI
Primary source
MGI:MGI:894320
See related
Ensembl:ENSMUSG00000026701 AllianceGenome:MGI:894320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPx; Aop2; CP-3; Ltw4; Ltw-4; NSGPx; ORF06; Prdx5; Brp-12; Lvtw-4; aiPLA2; LPCAT-5; 1-cysPrx; 1-Cys Prx; 9430088D19Rik
Summary
This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in colon adult (RPKM 178.6), lung adult (RPKM 85.0) and 27 other tissues See more
Orthologs
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Genomic context

See Prdx6 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161067682..161078780, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161240112..161251210, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51252 Neighboring gene solute carrier family 9, member C2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02818 Neighboring gene STARR-positive B cell enhancer ABC_E9490 Neighboring gene STARR-positive B cell enhancer ABC_E5834 Neighboring gene STARR-seq mESC enhancer starr_02820 Neighboring gene STARR-seq mESC enhancer starr_02821 Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02822 Neighboring gene STARR-seq mESC enhancer starr_02823 Neighboring gene STARR-seq mESC enhancer starr_02824 Neighboring gene tumor necrosis factor (ligand) superfamily, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (9)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 1-acylglycerophosphocholine O-acyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
enables phospholipase A2 activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-6
Names
1-Cys peroxiredoxin
LPC acyltransferase 5
acidic calcium-independent phospholipase A2
anti-oxidant protein 2, related sequence 3
antioxidant protein 2
glutathione-dependent peroxiredoxin
lyso-PC acyltransferase 5
lysophosphatidylcholine acyltransferase 5
non-selenium glutathione peroxidase
peroxiredoxin 5, related sequence 3
peroxiredoxin 6, related sequence 3
NP_001290337.1
NP_031479.1
XP_030099023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303408.1NP_001290337.1  peroxiredoxin-6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses an alternate translation start site, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115751
    Consensus CDS
    CCDS78724.1
    UniProtKB/Swiss-Prot
    O08709, Q91WT2, Q9QWP4, Q9QWW0
    UniProtKB/TrEMBL
    D3Z0Y2, Q53ZU7
    Related
    ENSMUSP00000050703.5, ENSMUST00000051925.5
    Conserved Domains (1) summary
    cd03016
    Location:4198
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
  2. NM_007453.4NP_031479.1  peroxiredoxin-6 isoform 1

    See identical proteins and their annotated locations for NP_031479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC115751, AK030413, AK157820
    Consensus CDS
    CCDS15415.1
    UniProtKB/Swiss-Prot
    O08709, Q91WT2, Q9QWP4, Q9QWW0
    UniProtKB/TrEMBL
    Q53ZU7, Q6GT24
    Related
    ENSMUSP00000071636.6, ENSMUST00000071718.12
    Conserved Domains (1) summary
    cd03016
    Location:7222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RNA

  1. NR_130150.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Use of an alternate translational start codon located further downstream would create an ORF that encodes a non-functional protein.
    Source sequence(s)
    AC115751

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161067682..161078780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243163.1XP_030099023.1  peroxiredoxin-6 isoform X1

    UniProtKB/Swiss-Prot
    O08709, Q91WT2, Q9QWP4, Q9QWW0
    UniProtKB/TrEMBL
    D3Z0Y2, Q53ZU7
    Conserved Domains (1) summary
    cd03016
    Location:4198
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...