Format

Send to:

Choose Destination

Prdx6 peroxiredoxin 6 [ Mus musculus (house mouse) ]

Gene ID: 11758, updated on 12-Aug-2018

Summary

Official Symbol
Prdx6provided by MGI
Official Full Name
peroxiredoxin 6provided by MGI
Primary source
MGI:MGI:894320
See related
Ensembl:ENSMUSG00000026701 Vega:OTTMUSG00000016463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GPx; Aop2; CP-3; Ltw4; Ltw-4; NSGPx; ORF06; Prdx5; Brp-12; Lvtw-4; aiPLA2; 1-cysPrx; AA690119; 1-Cys Prx; 9430088D19Rik
Summary
This gene encodes a member of the peroxiredoxin family of peroxidases. The encoded protein is a bifunctional enzyme that has glutathione peroxidase and phospholipase activities. This protein is an antioxidant that reduces peroxidized membrane phospholipids and plays an important role in phospholipid homeostasis based on its ability to generate lysophospholipid substrate for the remodeling pathway of phospholipid synthesis. Mice lacking this gene are sensitive to oxidant stress, have altered lung phospholipid metabolism and susceptible to skin tumorigenesis. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in colon adult (RPKM 178.6), lung adult (RPKM 85.0) and 27 other tissues See more
Orthologs

Genomic context

See Prdx6 in Genome Data Viewer
Location:
1 H2.1; 1 69.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (161240112..161251210, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (163170243..163181297, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 45 Neighboring gene testis expressed 50 Neighboring gene solute carrier family 9, member C2 pseudogene Neighboring gene guanosine diphosphate (GDP) dissociation inhibitor 1 pseudogene Neighboring gene tumor necrosis factor (ligand) superfamily, member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0106

Gene Ontology Provided by MGI

Function Evidence Code Pubs
antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
calcium-independent phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
peroxiredoxin activity IEA
Inferred from Electronic Annotation
more info
 
phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
bleb assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell redox homeostasis IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification ISO
Inferred from Sequence Orthology
more info
 
cellular response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycerophospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen peroxide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydrogen peroxide catabolic process ISO
Inferred from Sequence Orthology
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
response to reactive oxygen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
lysosome IEA
Inferred from Electronic Annotation
more info
 
mitochondrion HDA PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxiredoxin-6
Names
1-Cys peroxiredoxin
acidic calcium-independent phospholipase A2
anti-oxidant protein 2, related sequence 3
antioxidant protein 2
non-selenium glutathione peroxidase
peroxiredoxin 5, related sequence 3
peroxiredoxin 6, related sequence 3
NP_001290337.1
NP_031479.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303408.1NP_001290337.1  peroxiredoxin-6 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses an alternate translation start site, compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC115751
    Consensus CDS
    CCDS78724.1
    UniProtKB/TrEMBL
    D3Z0Y2
    Related
    ENSMUSP00000050703.4, OTTMUSP00000017704, ENSMUST00000051925.4, OTTMUST00000039667
    Conserved Domains (2) summary
    COG0450
    Location:8176
    AhpC; Alkyl hydroperoxide reductase subunit AhpC (peroxiredoxin) [Defense mechanisms]
    cd03016
    Location:4198
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...
  2. NM_007453.4NP_031479.1  peroxiredoxin-6 isoform 1

    See identical proteins and their annotated locations for NP_031479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC115751, AK030413, AK157820
    Consensus CDS
    CCDS15415.1
    UniProtKB/Swiss-Prot
    O08709
    UniProtKB/TrEMBL
    Q6GT24
    Related
    ENSMUSP00000071636.5, OTTMUSP00000017703, ENSMUST00000071718.11, OTTMUST00000039666
    Conserved Domains (1) summary
    cd03016
    Location:7222
    PRX_1cys; Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by ...

RNA

  1. NR_130150.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks one internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Use of an alternate translational start codon located further downstream would create an ORF that encodes a non-functional protein.
    Source sequence(s)
    AC115751

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    161240112..161251210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center