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Aoc3 amine oxidase, copper containing 3 [ Mus musculus (house mouse) ]

Gene ID: 11754, updated on 8-Feb-2024

Summary

Official Symbol
Aoc3provided by MGI
Official Full Name
amine oxidase, copper containing 3provided by MGI
Primary source
MGI:MGI:1306797
See related
Ensembl:ENSMUSG00000019326 AllianceGenome:MGI:1306797
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SSAO; VAP1
Summary
Predicted to enable several functions, including metal ion binding activity; primary amine oxidase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including leukocyte migration involved in inflammatory response; negative regulation of primary amine oxidase activity; and positive regulation of glucose transmembrane transport. Predicted to be located in several cellular components, including cell surface; extracellular space; and microvillus. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including Golgi apparatus; early endosome; and endoplasmic reticulum. Is expressed in several structures, including alimentary system; axial skeleton; cardiovascular system; sensory organ; and skin. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AOC3 (amine oxidase copper containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 188.2), genital fat pad adult (RPKM 119.5) and 4 other tissues See more
Orthologs
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Genomic context

See Aoc3 in Genome Data Viewer
Location:
11 D; 11 64.72 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101221432..101230256)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101330606..101339430)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7066 Neighboring gene proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Neighboring gene amine oxidase copper containing 2 Neighboring gene glucose-6-phosphatase catalytic subunit 1 Neighboring gene predicted gene, 51949

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables copper ion binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables quinone binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in amine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in amine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in eating behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of primary amine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucose transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
involved_in response to antibiotic IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to antibiotic ISO
Inferred from Sequence Orthology
more info
 
involved_in response to immobilization stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
membrane primary amine oxidase
Names
VAP-1
copper amine oxidase
semicarbazide-sensitive amine oxidase
vascular adhesion protein 1
NP_033805.1
XP_006532104.1
XP_017169719.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009675.2NP_033805.1  membrane primary amine oxidase

    See identical proteins and their annotated locations for NP_033805.1

    Status: VALIDATED

    Source sequence(s)
    AL590969
    Consensus CDS
    CCDS25465.1
    UniProtKB/Swiss-Prot
    A2A4I7, O70423, Q66JM4, Q9R055
    Related
    ENSMUSP00000099394.4, ENSMUST00000103105.10
    Conserved Domains (3) summary
    pfam01179
    Location:315721
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
    pfam02727
    Location:66152
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:169269
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101221432..101230256
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532041.5XP_006532104.1  membrane primary amine oxidase isoform X2

    Conserved Domains (1) summary
    pfam01179
    Location:7178
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
  2. XM_017314230.2XP_017169719.1  membrane primary amine oxidase isoform X1

    Conserved Domains (1) summary
    pfam01179
    Location:11196
    Cu_amine_oxid; Copper amine oxidase, enzyme domain