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Anxa3 annexin A3 [ Mus musculus (house mouse) ]

Gene ID: 11745, updated on 3-Apr-2024

Summary

Official Symbol
Anxa3provided by MGI
Official Full Name
annexin A3provided by MGI
Primary source
MGI:MGI:1201378
See related
Ensembl:ENSMUSG00000029484 AllianceGenome:MGI:1201378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Anx3
Summary
Predicted to enable several functions, including calcium-dependent phospholipid binding activity; calcium-dependent protein binding activity; and phospholipase A2 inhibitor activity. Predicted to be involved in several processes, including neutrophil degranulation; positive regulation of endothelial cell migration; and regulation of nucleobase-containing compound metabolic process. Located in collagen-containing extracellular matrix. Is expressed in several structures, including Meckel's cartilage; brain meninges; cardiovascular system; hindlimb interdigital region; and rectum. Orthologous to human ANXA3 (annexin A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 32.8), placenta adult (RPKM 31.7) and 23 other tissues See more
Orthologs
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Genomic context

See Anxa3 in Genome Data Viewer
Location:
5 E3; 5 47.29 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (96941257..96993825)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (96793385..96845968)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Fraser extracellular matrix complex subunit 1 Neighboring gene STARR-seq mESC enhancer starr_13678 Neighboring gene predicted gene, 52781 Neighboring gene predicted gene, 32995 Neighboring gene STARR-seq mESC enhancer starr_13679 Neighboring gene STARR-positive B cell enhancer mm9_chr5:97283346-97283646 Neighboring gene predicted gene, 33100 Neighboring gene predicted gene, 24623

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phospholipase A2 inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in specific granule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
annexin A3
Names
35-alpha calcimedin
PAP-III
annexin III
annexin-3
lipocortin III
placental anticoagulant protein III
NP_001407036.1
NP_001407037.1
NP_001407038.1
NP_038498.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420107.1NP_001407036.1  annexin A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121829, AC121887
    UniProtKB/Swiss-Prot
    O35639, Q3UBI0
  2. NM_001420108.1NP_001407037.1  annexin A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC121829, AC121887
    UniProtKB/Swiss-Prot
    O35639, Q3UBI0
  3. NM_001420109.1NP_001407038.1  annexin A3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC121829, AC121887
  4. NM_013470.3NP_038498.2  annexin A3 isoform 1

    See identical proteins and their annotated locations for NP_038498.2

    Status: VALIDATED

    Source sequence(s)
    AC121829, AC121887
    Consensus CDS
    CCDS51568.1
    UniProtKB/Swiss-Prot
    O35639, Q3UBI0
    UniProtKB/TrEMBL
    Q3TFK4, Q3U737, Q8C1X9
    Related
    ENSMUSP00000031447.8, ENSMUST00000031447.12
    Conserved Domains (1) summary
    pfam00191
    Location:94159
    Annexin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    96941257..96993825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)