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GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 [ Homo sapiens (human) ]

Gene ID: 117248, updated on 18-Aug-2020

Summary

Official Symbol
GALNT15provided by HGNC
Official Full Name
polypeptide N-acetylgalactosaminyltransferase 15provided by HGNC
Primary source
HGNC:HGNC:21531
See related
Ensembl:ENSG00000131386 MIM:615131
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIH5; GALNT7; GALNT13; GALNTL2; GALNACT15; pp-GalNAc-T15
Expression
Broad expression in fat (RPKM 7.2), brain (RPKM 5.4) and 14 other tissues See more
Orthologs

Genomic context

See GALNT15 in Genome Data Viewer
Location:
3p25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (16174579..16248224)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (16216086..16286033)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986064 Neighboring gene Sharpr-MPRA regulatory region 11264 Neighboring gene oxidoreductase NAD binding domain containing 1 Neighboring gene diphthamide biosynthesis 3 Neighboring gene THAP domain containing 5 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H1113

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polypeptide N-acetylgalactosaminyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
transport vesicle IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
polypeptide N-acetylgalactosaminyltransferase 15
Names
UDP-GalNAc transferase T15
UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 2
galNAc-T-like protein 2
polypeptide GalNAc transferase 15
polypeptide GalNAc transferase-like protein 2
polypeptide N-acetylgalactosaminyltransferase 13
polypeptide N-acetylgalactosaminyltransferase-like protein 2
pp-GaNTase-like protein 2
pregnancy-induced hypertension syndrome-related protein 5
protein-UDP acetylgalactosaminyltransferase-like protein 2
NP_001305980.1
NP_001305981.1
NP_473451.3
XP_005264909.1
XP_016861171.1
XP_016861172.1
XP_016861173.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319051.2NP_001305980.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3'-terminal exon compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC087858, AC090953, AL832736, DA279091
    Consensus CDS
    CCDS82742.1
    UniProtKB/TrEMBL
    C9JGI4
    Related
    ENSP00000395873.1, ENST00000437509.3
    Conserved Domains (4) summary
    cd02510
    Location:194493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507614
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505592
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191447
    Glyco_tranf_2_3; Glycosyltransferase like family 2
  2. NM_001319052.2NP_001305981.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons in the 5' coding region, and uses an alternate 5'-terminal exon and a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC090953, BC030625, BG926921, BQ005863, BQ014148, BX088662, DA358505
    UniProtKB/TrEMBL
    Q4G146
    Related
    ENSP00000480229.1, ENST00000617544.3
    Conserved Domains (3) summary
    cd00161
    Location:37160
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:35158
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:123
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. NM_054110.5NP_473451.3  polypeptide N-acetylgalactosaminyltransferase 15 isoform 1

    See identical proteins and their annotated locations for NP_473451.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC090953, AK312425, AY035399
    Consensus CDS
    CCDS33711.1
    UniProtKB/Swiss-Prot
    Q8N3T1
    Related
    ENSP00000344260.5, ENST00000339732.10
    Conserved Domains (4) summary
    cd02510
    Location:194493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507630
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505628
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191447
    Glyco_tranf_2_3; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    16174579..16248224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005684.2XP_016861173.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X3

  2. XM_017005683.2XP_016861172.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X2

    UniProtKB/TrEMBL
    B3KT16
    Conserved Domains (3) summary
    cd00161
    Location:240363
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:238361
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:1226
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
  3. XM_005264852.5XP_005264909.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X1

    Conserved Domains (4) summary
    cd02510
    Location:194493
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:507591
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:505591
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam13641
    Location:191447
    Glyco_tranf_2_3; Glycosyltransferase like family 2
  4. XM_017005682.2XP_016861171.1  polypeptide N-acetylgalactosaminyltransferase 15 isoform X2

    UniProtKB/TrEMBL
    B3KT16
    Conserved Domains (3) summary
    cd00161
    Location:240363
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:238361
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    cl11394
    Location:1226
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold
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