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ADCYAP1R1 ADCYAP receptor type I [ Homo sapiens (human) ]

Gene ID: 117, updated on 7-Jun-2020

Summary

Official Symbol
ADCYAP1R1provided by HGNC
Official Full Name
ADCYAP receptor type Iprovided by HGNC
Primary source
HGNC:HGNC:242
See related
Ensembl:ENSG00000078549 MIM:102981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC1; PAC1R; PACAPR; PACAPRI
Summary
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
Expression
Biased expression in brain (RPKM 39.8), adrenal (RPKM 5.5) and 1 other tissue See more
Orthologs

Genomic context

See ADCYAP1R1 in Genome Data Viewer
Location:
7p14.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (31052308..31111479)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (31092076..31151093)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375222 Neighboring gene growth hormone releasing hormone receptor Neighboring gene uncharacterized LOC105375221 Neighboring gene small integral membrane protein 14 pseudogene Neighboring gene uncharacterized LOC107986781 Neighboring gene uncharacterized LOC107986782

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.
NHGRI GWA Catalog
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylation factor binding IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase binding IEA
Inferred from Electronic Annotation
more info
 
neuropeptide binding IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
vasoactive intestinal polypeptide receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
development of primary female sexual characteristics IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal response to stress IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell death IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of calcium ion transport into cytosol IEA
Inferred from Electronic Annotation
more info
 
positive regulation of inositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
caveola IEA
Inferred from Electronic Annotation
more info
 
cell surface IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pituitary adenylate cyclase-activating polypeptide type I receptor
Names
PACAP receptor 1
PACAP type I receptor
PACAP-R1
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop
pituitary adenylate cyclase-activating polypeptide type 1 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029869.1 RefSeqGene

    Range
    5001..64018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001118.5NP_001109.2  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 3 precursor

    See identical proteins and their annotated locations for NP_001109.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC006466, AK290046, CA432770, DA809763
    Consensus CDS
    CCDS5433.1
    UniProtKB/Swiss-Prot
    P41586
    UniProtKB/TrEMBL
    A0A090N8F8
    Related
    ENSP00000306620.4, ENST00000304166.8
    Conserved Domains (2) summary
    pfam02793
    Location:52137
    HRM; Hormone receptor domain
    cd15987
    Location:150417
    7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  2. NM_001199635.1NP_001186564.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_001186564.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC006466, BC136267, CA432770, DA809763
    Consensus CDS
    CCDS56480.1
    UniProtKB/Swiss-Prot
    P41586
    Related
    ENSP00000483721.1, ENST00000614107.4
    Conserved Domains (2) summary
    pfam02793
    Location:52137
    HRM; Hormone receptor domain
    cd15987
    Location:150445
    7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors
  3. NM_001199636.2NP_001186565.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AC006466, BC143679, CA432770, DA809763
    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:150423
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    HRM; Hormone receptor domain
  4. NM_001199637.2NP_001186566.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001186566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive exons in the upstream region and one exon in the downstream region in the CDS, as compared to variant 1. The resulting isoform (3) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC006466, AK226138, CA432770, DA809763
    Consensus CDS
    CCDS56481.1
    UniProtKB/Swiss-Prot
    P41586
    Related
    ENSP00000387335.1, ENST00000409363.5
    Conserved Domains (2) summary
    pfam02793
    Location:52116
    HRM; Hormone receptor domain
    cd15987
    Location:129396
    7tmB1_PACAP-R1; pituitary adenylate cyclase-activating polypeptide type 1 receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    31052308..31111479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017011738.2XP_016867227.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X4

  2. XM_005249618.5XP_005249675.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X5

    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:93339
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:4680
    HRM; Hormone receptor domain
  3. XM_006715645.3XP_006715708.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1

    See identical proteins and their annotated locations for XP_006715708.1

    Related
    ENSP00000386395.1, ENST00000409489.5
    Conserved Domains (2) summary
    pfam00002
    Location:150424
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52137
    HRM; Hormone receptor domain
  4. XM_017011736.2XP_016867225.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2

    Conserved Domains (2) summary
    pfam00002
    Location:143417
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52130
    HRM; Hormone receptor domain
  5. XM_017011737.2XP_016867226.1  pituitary adenylate cyclase-activating polypeptide type I receptor isoform X3

    UniProtKB/Swiss-Prot
    P41586
    Conserved Domains (2) summary
    pfam00002
    Location:129403
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:52116
    HRM; Hormone receptor domain
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