U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Aldoa aldolase A, fructose-bisphosphate [ Mus musculus (house mouse) ]

Gene ID: 11674, updated on 8-Jan-2023

Summary

Official Symbol
Aldoaprovided by MGI
Official Full Name
aldolase A, fructose-bisphosphateprovided by MGI
Primary source
MGI:MGI:87994
See related
Ensembl:ENSMUSG00000030695 AllianceGenome:MGI:87994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aldo1; Aldo-1
Summary
Enables fructose-bisphosphate aldolase activity and protease binding activity. Involved in positive regulation of cell migration. Located in Z disc; plasma membrane; and sperm fibrous sheath. Part of protein-containing complex. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 794.0), subcutaneous fat pad adult (RPKM 494.9) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Aldoa in Genome Data Viewer
Location:
7; 7 F3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126394406..126400166, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126795234..126800994, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene TLC domain containing 3B Neighboring gene RIKEN cDNA 4930451I11 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107164, AC124505.11

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose binding ISO
Inferred from Sequence Orthology
more info
 
enables fructose-bisphosphate aldolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fructose-bisphosphate aldolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fructose-bisphosphate aldolase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables fructose-bisphosphate aldolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables fructose-bisphosphate aldolase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
located_in heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm head ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fructose-bisphosphate aldolase A
Names
muscle-type aldolase
NP_001170778.1
NP_001170779.1
NP_031464.1
XP_006507272.1
XP_006507273.1
XP_030097861.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177307.2NP_001170778.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1).
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS52399.1
    UniProtKB/TrEMBL
    A0A8C6I6W4, A6ZI44, Q5FWB7
    Related
    ENSMUSP00000084846.5, ENSMUST00000087566.11
    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. NM_001177308.2NP_001170779.1  fructose-bisphosphate aldolase A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in its 5' end and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21845.1
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7
    Related
    ENSMUSP00000101955.2, ENSMUST00000106348.8
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  3. NM_001411901.1NP_001398830.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A0A8C6I6W4, A6ZI44
  4. NM_001411902.1NP_001398831.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A0A8C6I6W4, A6ZI44
  5. NM_001411903.1NP_001398832.1  fructose-bisphosphate aldolase A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/TrEMBL
    A0A8C6I6W4, A6ZI44
  6. NM_001411904.1NP_001398833.1  fructose-bisphosphate aldolase A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124505
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7
  7. NM_007438.5NP_031464.1  fructose-bisphosphate aldolase A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC124505
    Consensus CDS
    CCDS21845.1
    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7
    Related
    ENSMUSP00000032934.6, ENSMUST00000032934.12
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126394406..126400166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242001.1XP_030097861.1  fructose-bisphosphate aldolase A isoform X2

    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  2. XM_006507210.3XP_006507273.1  fructose-bisphosphate aldolase A isoform X2

    UniProtKB/Swiss-Prot
    P05064
    UniProtKB/TrEMBL
    Q5FWB7
    Conserved Domains (1) summary
    pfam00274
    Location:15364
    Glycolytic; Fructose-bisphosphate aldolase class-I
  3. XM_006507209.3XP_006507272.1  fructose-bisphosphate aldolase A isoform X1

    UniProtKB/TrEMBL
    A6ZI44
    Conserved Domains (1) summary
    pfam00274
    Location:69418
    Glycolytic; Fructose-bisphosphate aldolase class-I