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Ak4 adenylate kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 11639, updated on 9-Mar-2023

Summary

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Official Symbol
Ak4provided by MGI
Official Full Name
adenylate kinase 4provided by MGI
Primary source
MGI:MGI:87979
See related
Ensembl:ENSMUSG00000028527 AllianceGenome:MGI:87979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak3; AK 4; Ak-3; Ak-4; Ak3l1; D4Ertd274e
Summary
Predicted to enable nucleoside diphosphate kinase activity. Predicted to be involved in several processes, including nucleoside phosphate metabolic process; regulation of ATP biosynthetic process; and regulation of oxidative phosphorylation. Predicted to act upstream of or within phosphorylation. Located in mitochondrial matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 34.8), cerebellum adult (RPKM 9.7) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Ak4 in Genome Data Viewer
Location:
4 C6; 4 46.84 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (101273675..101324968)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (101416478..101467771)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130102H24 gene Neighboring gene RIKEN cDNA 0610043K17 gene Neighboring gene microRNA 101a Neighboring gene ribosomal protein L9 pseudogene Neighboring gene DnaJ heat shock protein family (Hsp40) member C6 Neighboring gene predicted gene, 36012 Neighboring gene leptin receptor overlapping transcript

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages. Chin WY, et al. Front Immunol, 2021. PMID 33790902, Free PMC Article
  2. Identification of a novel adenylate kinase system in the brain: cloning of the fourth adenylate kinase. Yoneda T, et al. Brain Res Mol Brain Res, 1998 Nov 20. PMID 9813319
  3. Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Noma T, et al. Biochem J, 2001 Aug 15. PMID 11485571, Free PMC Article
  4. Scrambler and yotari disrupt the disabled gene and produce a reeler-like phenotype in mice. Sheldon M, et al. Nature, 1997 Oct 16. PMID 9338784
  5. The gene encoding disabled-1 (DAB1), the intracellular adaptor of the Reelin pathway, reveals unusual complexity in human and mouse. Bar I, et al. J Biol Chem, 2003 Feb 21. PMID 12446734

See all (32) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1alpha and AMPK in Macrophages.
    Title: Adenylate Kinase 4 Promotes Inflammatory Gene Expression via Hif1α and AMPK in Macrophages.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleobase-containing compound kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables nucleoside diphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside triphosphate adenylate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphotransferase activity, phosphate group as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in AMP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in AMP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GTP metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside triphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in nucleoside triphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of oxidative phosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adenylate kinase 4, mitochondrial
Names
ATP-AMP transphosphorylase
GTP:AMP phosphotransferase AK4, mitochondrial
adenylate kinase 3 alpha-like 1
adenylate kinase 3-like 1
adenylate kinase isoenzyme 4, mitochondrial
NP_001171073.1
NP_001171075.1
NP_001171076.1
NP_033777.1
XP_006502748.1
XP_017175412.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177602.1 → NP_001171073.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_001171073.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK004491, AL845364, AV023306, BC086663, BY718404
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    A0A6P5PQY2, Q3U489
    Related
    ENSMUSP00000102559.2, ENSMUST00000106946.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

  2. NM_001177604.1 → NP_001171075.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_001171075.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK004491, AL845364, AV023306, BC086663, BY203078
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    A0A6P5PQY2, Q3U489
    Related
    ENSMUSP00000102558.2, ENSMUST00000106945.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

  3. NM_001177605.1 → NP_001171076.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_001171076.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK004491, AL845364, AV023306, BC086663, BY740484
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    A0A6P5PQY2, Q3U489
    Related
    ENSMUSP00000099841.2, ENSMUST00000102780.8
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

  4. NM_009647.5 → NP_033777.1  adenylate kinase 4, mitochondrial

    See identical proteins and their annotated locations for NP_033777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK004491, AL845364, AV023306, BC086663, CJ087385
    Consensus CDS
    CCDS18394.1
    UniProtKB/Swiss-Prot
    Q9R1X7, Q9WUR9
    UniProtKB/TrEMBL
    A0A6P5PQY2, Q3U489
    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 211
    adk; adenylate kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    101273675..101324968
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319923.2 → XP_017175412.1  adenylate kinase 4, mitochondrial isoform X1

    Conserved Domains (1) summary
    TIGR01351
    Location:7 → 171
    adk; adenylate kinase

  2. XM_006502685.3 → XP_006502748.1  adenylate kinase 4, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006502748.1

    Related
    ENSMUSP00000121112.2, ENSMUST00000155749.2
    Conserved Domains (1) summary
    TIGR01351
    Location:1 → 139
    adk; adenylate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUR9.1 GenPept UniProtKB/Swiss-Prot:Q9WUR9

Gene LinkOut

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