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Ak2 adenylate kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 11637, updated on 8-Feb-2024

Summary

Official Symbol
Ak2provided by MGI
Official Full Name
adenylate kinase 2provided by MGI
Primary source
MGI:MGI:87978
See related
Ensembl:ENSMUSG00000028792 AllianceGenome:MGI:87978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ak-2; D4Ertd220e
Summary
Predicted to enable adenylate kinase activity. Predicted to contribute to nucleobase-containing compound kinase activity. Predicted to be involved in ATP metabolic process and purine nucleotide metabolic process. Predicted to act upstream of or within phosphorylation. Located in sperm mitochondrial sheath. Is expressed in several structures, including alimentary system; brain; genitourinary system; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in reticular dysgenesis. Orthologous to human AK2 (adenylate kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 35.1), subcutaneous fat pad adult (RPKM 34.0) and 28 other tissues See more
Orthologs
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Genomic context

See Ak2 in Genome Data Viewer
Location:
4 D2.2; 4 62.62 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (128887017..128905322)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (128993224..129011529)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57685 Neighboring gene antizyme inhibitor 2 Neighboring gene predicted gene 15904 Neighboring gene STARR-positive B cell enhancer mm9_chr4:128639609-128639910 Neighboring gene STARR-positive B cell enhancer ABC_E3515 Neighboring gene STARR-positive B cell enhancer ABC_E122 Neighboring gene STARR-positive B cell enhancer ABC_E6222 Neighboring gene STARR-positive B cell enhancer ABC_E7990 Neighboring gene STARR-seq mESC enhancer starr_11473 Neighboring gene RIKEN cDNA 1700086P04 gene Neighboring gene STARR-positive B cell enhancer ABC_E10260 Neighboring gene STARR-positive B cell enhancer ABC_E3516 Neighboring gene ring finger protein 19B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (2)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables adenylate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables adenylate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to nucleobase-containing compound kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphotransferase activity, phosphate group as acceptor IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ADP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in AMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in dATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
PubMed 
located_in sperm mitochondrial sheath IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adenylate kinase 2, mitochondrial
Names
AK 2
ATP-AMP transphosphorylase 2
ATP:AMP phosphotransferase
adenylate monophosphate kinase
NP_001029138.1
NP_058591.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033966.4NP_001029138.1  adenylate kinase 2, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_001029138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AL607086
    Consensus CDS
    CCDS18680.1
    UniProtKB/Swiss-Prot
    A2A820, Q3THT3, Q3TI11, Q3TKI6, Q8C7I9, Q9CY37, Q9WTP6
    Related
    ENSMUSP00000030583.7, ENSMUST00000030583.13
    Conserved Domains (2) summary
    cd01428
    Location:17219
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam00406
    Location:20204
    ADK; Adenylate kinase
  2. NM_016895.4NP_058591.2  adenylate kinase 2, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_058591.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform b which has a shorter C-terminus, compared to isoform a.
    Source sequence(s)
    AL607086
    Consensus CDS
    CCDS18679.1
    UniProtKB/Swiss-Prot
    Q9WTP6
    Related
    ENSMUSP00000099664.5, ENSMUST00000102604.11
    Conserved Domains (2) summary
    cd01428
    Location:17219
    ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
    pfam00406
    Location:20204
    ADK; Adenylate kinase

RNA

  1. NR_138540.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' exon. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL607086, BM937796

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    128887017..128905322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)